Reactome | DLST transfers glutaryl to CoA

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DLST transfers glutaryl to CoA Show undefined attributes

authored	[InstanceEdit:9858583] Stephan, Ralf, 2024-01-13
catalystActivity	[CatalystActivity:9858591] peptide glutaryltransferase activity of OADH complex [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9858593] Stephan, Ralf, 2024-01-13
crossReference	[DatabaseIdentifier:9938951] RHEA:18011
dbId	9858590
displayName	DLST transfers glutaryl to CoA
edited	[InstanceEdit:9910822] Stephan, Ralf, 2024-05-21
eventOf	[Pathway:R-HSA-9858328] OADH complex synthesizes glutaryl-CoA from 2-OA - Homo sapiens
followingEvent	[Reaction:R-HSA-71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - Homo sapiens [Reaction:R-HSA-9858589] DLD dimer dehydrogenates dihydrolipoyl - Homo sapiens
input	[SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [EntityWithAccessionedSequence:R-HSA-9858581] GlutaryllipoH2-K110-DLST [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9853756] Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas [LiteratureReference:9858330] The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	DLST transfers glutaryl to CoA
orthologousEvent	[Reaction:R-DDI-9858590] DLST transfers glutaryl to CoA - Dictyostelium discoideum [Reaction:R-CEL-9858590] DLST transfers glutaryl to CoA - Caenorhabditis elegans [Reaction:R-DME-9858590] DLST transfers glutaryl to CoA - Drosophila melanogaster [Reaction:R-GGA-9858590] DLST transfers glutaryl to CoA - Gallus gallus [Reaction:R-XTR-9858590] DLST transfers glutaryl to CoA - Xenopus tropicalis [Reaction:R-DRE-9858590] DLST transfers glutaryl to CoA - Danio rerio [Reaction:R-SSC-9858590] DLST transfers glutaryl to CoA - Sus scrofa [Reaction:R-BTA-9858590] DLST transfers glutaryl to CoA - Bos taurus [Reaction:R-CFA-9858590] DLST transfers glutaryl to CoA - Canis familiaris [Reaction:R-RNO-9858590] DLST transfers glutaryl to CoA - Rattus norvegicus [Reaction:R-MMU-9858590] DLST transfers glutaryl to CoA - Mus musculus
output	[SimpleEntity:R-ALL-70955] GL-CoA [mitochondrial matrix] [EntityWithAccessionedSequence:R-HSA-9853485] LipoH2-K110-DLST [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-9858321] DHTKD1 dimer decarboxylates 2-OA - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2024-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9907756] D'Eustachio, Peter, 2024-04-17 [InstanceEdit:9939375] Hill, David P, 2025-02-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9858590
summation	[Summation:9859066] Dihydrolipoyl succinyl transferase (DLST), the E2 component ...
updateTrackers	[UpdateTracker:9939668] Update Tracker - [Reaction:9858590] DLST transfers glutaryl to CoA - v92:[removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9939668] Update Tracker - [Reaction:9858590] DLST transfers glutaryl to CoA - v92:[removeInput]
(hasEvent)	[Pathway:R-HSA-9858328] OADH complex synthesizes glutaryl-CoA from 2-OA
(precedingEvent)	[Reaction:R-HSA-71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 [Reaction:R-HSA-9858589] DLD dimer dehydrogenates dihydrolipoyl

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