Reactome | Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA

Schema > Reaction > Entries

Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA Show undefined attributes

catalystActivity	[CatalystActivity:71049] enoyl-CoA hydratase activity of ECHS1 hexamer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:77247] Gillespie, ME, 2003-09-19 00:00:00
crossReference	[DatabaseIdentifier:12667522] RHEA:26560 [DatabaseIdentifier:9977718] RHEA:26560
dbId	77314
displayName	Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA
eventOf	[Pathway:R-HSA-77352] Beta oxidation of butanoyl-CoA to acetyl-CoA - Homo sapiens
followingEvent	[Reaction:R-HSA-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H - Homo sapiens
input	[SimpleEntity:R-ALL-77313] Crotonoyl-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:77407] Enzymes of fatty acid metabolism. II. Properties of crystalline crotonase.
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA (2E)-butenoyl-CoA + H2O => (3S)-3-hydroxybutanoyl-CoA
orthologousEvent	[Reaction:R-DDI-77314] Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA - Dictyostelium discoideum [Reaction:R-CEL-77314] Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA - Caenorhabditis elegans [Reaction:R-DME-77314] Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA - Drosophila melanogaster [Reaction:R-GGA-77314] Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA - Gallus gallus [Reaction:R-XTR-77314] Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA - Xenopus tropicalis [Reaction:R-DRE-77314] Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA - Danio rerio [Reaction:R-SSC-77314] Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA - Sus scrofa [Reaction:R-BTA-77314] Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA - Bos taurus [Reaction:R-CFA-77314] Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA - Canis familiaris [Reaction:R-RNO-77314] Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA - Rattus norvegicus [Reaction:R-MMU-77314] Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA - Mus musculus
output	[SimpleEntity:R-ALL-77251] 3HB-CoA [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-77319] Butanoyl-CoA+FAD => Crotonoyl-CoA+FADH2 - Homo sapiens [Reaction:R-HSA-71046] glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-77314
summation	[Summation:178564] ECHS1 in the mitochondrial matrix hydrates (2E)-butenoyl-CoA...
updateTrackers	[UpdateTracker:9984576] Update Tracker - [Reaction:77314] Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA - v96:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9984576] Update Tracker - [Reaction:77314] Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA - v96:[modifyText]
(hasEvent)	[Pathway:R-HSA-77352] Beta oxidation of butanoyl-CoA to acetyl-CoA
(precedingEvent)	[Reaction:R-HSA-77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H