Reactome | Proline catabolism

Schema > Pathway > Entries

compartment	[Compartment:5462] mitochondrion
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11078355
displayName	Proline catabolism
eventOf	[Pathway:R-SPO-71291] Metabolism of amino acids and derivatives - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:10931] L-proline catabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SPO-70670] PRODH oxidises L-Pro to 1PYR-5COOH - Schizosaccharomyces pombe [Reaction:R-SPO-8955817] PRODH2 oxidises HPRO to 1PYR-3OH-5COOH - Schizosaccharomyces pombe
inferredFrom	[Pathway:R-HSA-70688] Proline catabolism - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Proline catabolism
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-70688
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SPO-71291] Metabolism of amino acids and derivatives
(inferredTo)	[Pathway:R-HSA-70688] Proline catabolism

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