Proline catabolism

Stable Identifier
R-HSA-70688
Type
Pathway
Species
Homo sapiens
Compartment
mitochondrion
ReviewStatus
5/5
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Proline catabolism
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Proline is catabolized in two steps to yield L-glutamate gamma-semialdehyde, which can react further with glutamate to yield ornithine and alpha-ketoglutarate (annotated as a reaction of amino acid synthesis and interconversion) or with NAD+ to yield glutamate and NADH + H+ (Phang et al. 2001).

Literature References
PubMed ID Title Journal Year
  The Metabolic and Molecular Bases of Inherited Disease, 8th ed

Beaudet, AL, Scriver, CR, Sly, WS, Valle, D

  2001
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
proline catabolic process (0006562)
Orthologous Events
Proline catabolism (Bos taurus)
Proline catabolism (Caenorhabditis elegans)
Proline catabolism (Canis familiaris)
Proline catabolism (Danio rerio)
Proline catabolism (Dictyostelium discoideum)
Proline catabolism (Drosophila melanogaster)
Proline catabolism (Gallus gallus)
Proline catabolism (Mus musculus)
Proline catabolism (Rattus norvegicus)
Proline catabolism (Saccharomyces cerevisiae)
Proline catabolism (Schizosaccharomyces pombe)
Proline catabolism (Sus scrofa)
Proline catabolism (Xenopus tropicalis)
Authored
D'Eustachio, P  (2003-06-24)
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