Reactome | L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate

Schema > Reaction > Entries

L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate Show undefined attributes

category	transition
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:12667666] RHEA:28235
dbId	70655
displayName	L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate
eventOf	[Pathway:R-HSA-8964539] Glutamate and glutamine metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-6783955] PYCR3 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Homo sapiens [Reaction:R-HSA-6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Homo sapiens [Reaction:R-HSA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Homo sapiens
input	[SimpleEntity:R-ALL-31339] L-Glu5S [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[Book:70631] The hyperornithinemias 0079130356 Scriver, Charles R The Metabolic and Molecular Bases of Inherited Disease, 8th ed
maxDepth	1
modified	[InstanceEdit:9927661] D'Eustachio, Peter, 2024-11-08
name	L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate L-glutamate 5-semialdehyde => (S)-1-pyrroline-5-carboxylate + H(+) + H2O
output	[SimpleEntity:R-ALL-113590] 1PYR-5COOH [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-70654] ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] - Homo sapiens [Reaction:R-HSA-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reverseReaction	[Reaction:R-HSA-70667] 1PYR-5COOH spontaneously hydrolyses to L-GluSS
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9927660] D'Eustachio, Peter, 2024-11-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70655
summation	[Summation:178926] The interconversion of glutamate 5-semialdehyde (L-GluSS) an...
updateTrackers	[UpdateTracker:9791174] Update Tracker - [Reaction:70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate - v32:[modifyText] [UpdateTracker:9928423] Update Tracker - [Reaction:70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate - v91:[removeOutput] [UpdateTracker:9790575] Update Tracker - [Reaction:70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate - v33:[addOutput] [UpdateTracker:9781955] Update Tracker - [Reaction:70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate - v60:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791174] Update Tracker - [Reaction:70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate - v32:[modifyText] [UpdateTracker:9928423] Update Tracker - [Reaction:70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate - v91:[removeOutput] [UpdateTracker:9790575] Update Tracker - [Reaction:70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate - v33:[addOutput] [UpdateTracker:9781955] Update Tracker - [Reaction:70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate - v60:[modifyText]
(hasEvent)	[Pathway:R-HSA-8964539] Glutamate and glutamine metabolism
(precedingEvent)	[Reaction:R-HSA-6783955] PYCR3 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Reaction:R-HSA-6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro [Reaction:R-HSA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro