Reactome | PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

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PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro Show undefined attributes

authored	[InstanceEdit:6783946] D'Eustachio, Peter, 2015-06-17
catalystActivity	[CatalystActivity:6783944] pyrroline-5-carboxylate reductase activity of PYCR2 decamer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643784] pyrroline-5-carboxylate reductase activity of PYCR2 decamer [mitochondrial matrix] Functional specialization in proline biosynthesis of melanoma
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6783946] D'Eustachio, Peter, 2015-06-17
crossReference	[DatabaseIdentifier:12668122] RHEA:14111 [DatabaseIdentifier:9925796] RHEA:14111
dbId	6783939
displayName	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro
edited	[InstanceEdit:6783946] D'Eustachio, Peter, 2015-06-17
eventOf	[Pathway:R-HSA-8964539] Glutamate and glutamine metabolism - Homo sapiens
input	[SimpleEntity:R-ALL-35305] 1PYR-5COOH [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6783923] Functional specialization in proline biosynthesis of melanoma [LiteratureReference:70647] Crystal structure of human recombinant ornithine aminotransferase. [LiteratureReference:70657] Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH. [LiteratureReference:6783947] Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro 1-pyrroline-5-carboxylate + 2 H(+) + NADPH => L-proline + NADP(+)
orthologousEvent	[Reaction:R-BTA-6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Bos taurus [Reaction:R-PFA-6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Plasmodium falciparum [Reaction:R-SCE-6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Saccharomyces cerevisiae [Reaction:R-SPO-6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Schizosaccharomyces pombe [Reaction:R-DDI-6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Dictyostelium discoideum [Reaction:R-CEL-6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Caenorhabditis elegans [Reaction:R-DME-6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Drosophila melanogaster [Reaction:R-GGA-6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Gallus gallus [Reaction:R-XTR-6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Xenopus tropicalis [Reaction:R-DRE-6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Danio rerio [Reaction:R-SSC-6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Sus scrofa [Reaction:R-CFA-6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Canis familiaris [Reaction:R-RNO-6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Rattus norvegicus [Reaction:R-MMU-6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Mus musculus
output	[SimpleEntity:R-ALL-113538] L-Pro [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790586] Jassal, Bijay, 2015-08-13 [InstanceEdit:9927660] D'Eustachio, Peter, 2024-11-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6783939
summation	[Summation:6783949] Pyrroline-5-carboxylate reductase 2 (PYCR2) catalyzes the re...
updateTrackers	[UpdateTracker:9928453] Update Tracker - [Reaction:6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - v91:[add_removeInput, add_removeOutput, modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9928453] Update Tracker - [Reaction:6783939] PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - v91:[add_removeInput, add_removeOutput, modifyText, removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-8964539] Glutamate and glutamine metabolism

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