Reactome | glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]

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glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] Show undefined attributes

authored	[InstanceEdit:517475] D'Eustachio, P, 2010-02-18
catalystActivity	[CatalystActivity:508035] delta1-pyrroline-5-carboxylate synthetase activity of P5CS dimers [mitochondrial inner membrane]
catalystActivityReference	[CatalystActivityReference:9643295] delta1-pyrroline-5-carboxylate synthetase activity of P5CS dimers [mitochondrial inner membrane] Molecular enzymology of mammalian Delta1-pyrroline-5-carboxylate synthase. Alternative splice donor utilization generates isoforms with different sensitivity to ornithine inhibition
category	transition
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:508032] D'Eustachio, P, 2010-02-10
crossReference	[DatabaseIdentifier:12667667] RHEA:33208 [DatabaseIdentifier:9925798] RHEA:33208
dbId	508040
displayName	glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]
edited	[InstanceEdit:517475] D'Eustachio, P, 2010-02-18
eventOf	[Pathway:R-HSA-8964539] Glutamate and glutamine metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] - Homo sapiens [Reaction:R-HSA-70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate - Homo sapiens
input	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:508038] Molecular enzymology of mammalian Delta1-pyrroline-5-carboxylate synthase. Alternative splice donor utilization generates isoforms with different sensitivity to ornithine inhibition
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] ATP + H(+) + L-glutamate + NADPH => ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate
orthologousEvent	[Reaction:R-CEL-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] - Caenorhabditis elegans [Reaction:R-DME-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] - Drosophila melanogaster [Reaction:R-MMU-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] - Mus musculus [Reaction:R-SCE-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] - Saccharomyces cerevisiae [Reaction:R-SPO-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] - Schizosaccharomyces pombe [Reaction:R-RNO-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] - Rattus norvegicus [Reaction:R-GGA-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] - Gallus gallus [Reaction:R-XTR-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] - Xenopus tropicalis [Reaction:R-SSC-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] - Sus scrofa [Reaction:R-BTA-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] - Bos taurus [Reaction:R-CFA-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] - Canis familiaris
output	[SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [SimpleEntity:R-ALL-31339] L-Glu5S [mitochondrial matrix] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) - Homo sapiens [Reaction:R-HSA-70609] glutamine + H2O => glutamate + NH4+ (GLS) - Homo sapiens [Reaction:R-HSA-70654] ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] - Homo sapiens
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:532425] Jassal, Bijay, 2010-02-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-508040
summation	[Summation:508057] Delta-1-pyrroline-5-carboxylate synthetase associated with t...

Referrals

(hasEvent)	[Pathway:R-HSA-8964539] Glutamate and glutamine metabolism
(precedingEvent)	[Reaction:R-HSA-70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] [Reaction:R-HSA-70655] L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate

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