Reactome | argininosuccinate <=> fumarate + arginine

argininosuccinate <=> fumarate + arginine

Stable Identifier

R-HSA-70573

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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argininosuccinate <=> fumarate + arginine

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Cytosolic argininosuccinate lyase (ASL) catalyzes the reversible reaction of argininosuccinate to form fumarate and arginine. The enzyme is a homotetramer (Turner et al. 1997). The function of the human enzyme in vivo is inferred from the defective argininosuccinate lyase enzyme activity observed in patients with mutant forms of the ASL gene (e.g., Walker et al. 1990).

Literature References

PubMed ID	Title	Journal	Year
9256435	Human argininosuccinate lyase: a structural basis for intragenic complementation Turner, MA, Simpson, A, McInnes, RR, Howell, PL	Proc Natl Acad Sci U S A	1997
2263616	Molecular analysis of human argininosuccinate lyase: mutant characterization and alternative splicing of the coding region Walker, DC, McCloskey, DA, Simard, LR, McInnes, RR	Proc Natl Acad Sci U S A	1990