argininosuccinate <=> fumarate + arginine

Stable Identifier
R-HSA-70573
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic argininosuccinate lyase (ASL) catalyzes the reversible reaction of argininosuccinate to form fumarate and arginine. The enzyme is a homotetramer (Turner et al. 1997). The function of the human enzyme in vivo is inferred from the defective argininosuccinate lyase enzyme activity observed in patients with mutant forms of the ASL gene (e.g., Walker et al. 1990).

Literature References
PubMed ID Title Journal Year
2263616 Molecular analysis of human argininosuccinate lyase: mutant characterization and alternative splicing of the coding region

Walker, DC, McCloskey, DA, Simard, LR, McInnes, RR

Proc Natl Acad Sci U S A 1990
9256435 Human argininosuccinate lyase: a structural basis for intragenic complementation

Turner, MA, Simpson, A, McInnes, RR, Howell, PL

Proc Natl Acad Sci U S A 1997
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
argininosuccinate lyase activity of ASL tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored