Reactome | Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A

Schema > Reaction > Entries

Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A Show undefined attributes

catalystActivity	[CatalystActivity:10447942] phosphoprotein phosphatase activity of CDC25A [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10447944
displayName	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A
eventOf	[Pathway:R-SSC-69202] Cyclin E associated events during G1/S transition - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-SSC-69200] Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes - Sus scrofa [Reaction:R-SSC-188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 - Sus scrofa [Reaction:R-SSC-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Sus scrofa
inferredFrom	[Reaction:R-HSA-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A - Homo sapiens
input	[Complex:R-SSC-68377] Cyclin E:p-CDK2 [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A
output	[Complex:R-SSC-68374] CCNE:CDK2 [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm]
precedingEvent	[Reaction:R-SSC-69195] Phosphorylation of Cyclin E:CDK2 complexes by WEE1 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-69199
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-69202] Cyclin E associated events during G1/S transition
(precedingEvent)	[Pathway:R-SSC-69200] Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes [Reaction:R-SSC-188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 [Reaction:R-SSC-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21
(inferredTo)	[Reaction:R-HSA-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A