Reactome | Phosphorylation of Cyclin E:CDK2 complexes by WEE1

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Phosphorylation of Cyclin E:CDK2 complexes by WEE1 Show undefined attributes

catalystActivity	[CatalystActivity:69254] protein tyrosine kinase activity of WEE1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
dbId	69195
deleted	[Deleted:737631] Deletion of instance: 69636 [Deleted:737640] Deletion of instance: 69634
displayName	Phosphorylation of Cyclin E:CDK2 complexes by WEE1
eventOf	[Pathway:R-HSA-69202] Cyclin E associated events during G1/S transition - Homo sapiens
figure	[Figure:72787] /figures/cycline_cdk2_p.jpg
followingEvent	[Reaction:R-HSA-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:1043034] negative regulation of G1/S transition of mitotic cell cycle
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-68374] CCNE:CDK2 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:213358] Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers [LiteratureReference:77500] Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Phosphorylation of Cyclin E:CDK2 complexes by WEE1
negativePrecedingEvent	[NegativePrecedingEvent:9763996] Futile Cycle: Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A
orthologousEvent	[Reaction:R-DDI-69195] Phosphorylation of Cyclin E:CDK2 complexes by WEE1 - Dictyostelium discoideum [Reaction:R-DME-69195] Phosphorylation of Cyclin E:CDK2 complexes by WEE1 - Drosophila melanogaster [Reaction:R-GGA-69195] Phosphorylation of Cyclin E:CDK2 complexes by WEE1 - Gallus gallus [Reaction:R-XTR-69195] Phosphorylation of Cyclin E:CDK2 complexes by WEE1 - Xenopus tropicalis [Reaction:R-DRE-69195] Phosphorylation of Cyclin E:CDK2 complexes by WEE1 - Danio rerio [Reaction:R-SSC-69195] Phosphorylation of Cyclin E:CDK2 complexes by WEE1 - Sus scrofa [Reaction:R-BTA-69195] Phosphorylation of Cyclin E:CDK2 complexes by WEE1 - Bos taurus [Reaction:R-CFA-69195] Phosphorylation of Cyclin E:CDK2 complexes by WEE1 - Canis familiaris [Reaction:R-RNO-69195] Phosphorylation of Cyclin E:CDK2 complexes by WEE1 - Rattus norvegicus [Reaction:R-MMU-69195] Phosphorylation of Cyclin E:CDK2 complexes by WEE1 - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-68377] Cyclin E:p-CDK2 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-157906] Translocation of Cyclin E:Cdk2 complex to the nucleus - Homo sapiens
regulatedBy	[PositiveRegulation:9605532] Positive regulation by 'CABLES1 [nucleoplasm]'
regulationReference	[RegulationReference:9641985] Positive regulation by 'CABLES1 [nucleoplasm]' Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-69195
summation	[Summation:213353] WEE1 phosphorylates CDK2, inhibiting entry into S-phase (Wat...
updateTrackers	[UpdateTracker:9792040] Update Tracker - [Reaction:69195] Phosphorylation of Cyclin E:CDK2 complexes by WEE1 - v24:[addSummation] [UpdateTracker:9779546] Update Tracker - [Reaction:69195] Phosphorylation of Cyclin E:CDK2 complexes by WEE1 - v65:[addRegulator, modifyText] [UpdateTracker:9782976] Update Tracker - [Reaction:69195] Phosphorylation of Cyclin E:CDK2 complexes by WEE1 - v58:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9792040] Update Tracker - [Reaction:69195] Phosphorylation of Cyclin E:CDK2 complexes by WEE1 - v24:[addSummation] [UpdateTracker:9779546] Update Tracker - [Reaction:69195] Phosphorylation of Cyclin E:CDK2 complexes by WEE1 - v65:[addRegulator, modifyText] [UpdateTracker:9782976] Update Tracker - [Reaction:69195] Phosphorylation of Cyclin E:CDK2 complexes by WEE1 - v58:[addLiteratureReference]
(replacementInstances)	[Deleted:737631] Deletion of instance: 69636 [Deleted:737640] Deletion of instance: 69634
(hasEvent)	[Pathway:R-HSA-69202] Cyclin E associated events during G1/S transition
(precedingEvent)	[Reaction:R-HSA-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A

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