Reactome | 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one

Schema > Reaction > Entries

4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one Show undefined attributes

authored	[InstanceEdit:196418] D'Eustachio, P, 2007-04-21 18:31:40
catalystActivity	[CatalystActivity:194724] 3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity of NSDHL [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:194683] D'Eustachio, P, 2007-03-22 16:07:19
crossReference	[DatabaseIdentifier:9945108] RHEA:33448
dbId	194642
displayName	4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one
edited	[InstanceEdit:196418] D'Eustachio, P, 2007-04-21 18:31:40
eventOf	[Pathway:R-HSA-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Homo sapiens
followingEvent	[Reaction:R-HSA-194689] 4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol - Homo sapiens
input	[SimpleEntity:R-ALL-194735] 4C4MZYMOL [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:194694] NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one 4beta-methylzymosterol-4alpha-carboxylate + NADP(+) => 3-dehydro-4-methylzymosterol + CO2 + NADPH
orthologousEvent	[Reaction:R-SCE-194642] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one - Saccharomyces cerevisiae [Reaction:R-SPO-194642] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one - Schizosaccharomyces pombe [Reaction:R-DDI-194642] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one - Dictyostelium discoideum [Reaction:R-GGA-194642] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one - Gallus gallus [Reaction:R-DRE-194642] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one - Danio rerio [Reaction:R-SSC-194642] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one - Sus scrofa [Reaction:R-BTA-194642] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one - Bos taurus [Reaction:R-CFA-194642] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one - Canis familiaris [Reaction:R-RNO-194642] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one - Rattus norvegicus [Reaction:R-MMU-194642] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one - Mus musculus
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-194667] dh4MZYMOL [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
precedingEvent	[Reaction:R-HSA-194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:196409] Jassal, B, 2007-04-21 18:33:24 [InstanceEdit:9953269] Hill, David P, 2025-05-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-194642
summation	[Summation:194655] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol and NAD+ re...
updateTrackers	[UpdateTracker:9953671] Update Tracker - [Reaction:194642] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one - v93:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9953671] Update Tracker - [Reaction:194642] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one - v93:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway)
(precedingEvent)	[Reaction:R-HSA-194689] 4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol