Reactome | MET receptor dimerizes

Schema > Reaction > Entries

MET receptor dimerizes Show undefined attributes

authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:6806955] Orlic-Milacic, Marija, 2015-10-28
dbId	6806957
displayName	MET receptor dimerizes
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
eventOf	[Pathway:R-HSA-6806942] MET Receptor Activation - Homo sapiens
followingEvent	[Reaction:R-HSA-6806974] MET dimers autophosphorylate - Homo sapiens
input	2 × [Complex:R-HSA-6800287] HGF dimer:MET [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6800292] Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor [LiteratureReference:6806963] Oligomerization-dependent changes in the thermodynamic properties of the TPR-MET receptor tyrosine kinase [LiteratureReference:8931730] Structural basis of hepatocyte growth factor/scatter factor and MET signalling
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	MET receptor dimerizes
orthologousEvent	[Reaction:R-GGA-6806957] MET receptor dimerizes - Gallus gallus [Reaction:R-XTR-6806957] MET receptor dimerizes - Xenopus tropicalis [Reaction:R-DRE-6806957] MET receptor dimerizes - Danio rerio [Reaction:R-SSC-6806957] MET receptor dimerizes - Sus scrofa [Reaction:R-BTA-6806957] MET receptor dimerizes - Bos taurus [Reaction:R-CFA-6806957] MET receptor dimerizes - Canis familiaris [Reaction:R-RNO-6806957] MET receptor dimerizes - Rattus norvegicus [Reaction:R-MMU-6806957] MET receptor dimerizes - Mus musculus
output	[Complex:R-HSA-6806956] HGF:MET dimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-6800298] HGF dimer binds MET - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6806957
summation	[Summation:6806960] Upon ligand binding, MET receptor forms homodimers. Interact...

Referrals

(hasEvent)	[Pathway:R-HSA-6806942] MET Receptor Activation
(precedingEvent)	[Reaction:R-HSA-6806974] MET dimers autophosphorylate