MET receptor dimerizes

Stable Identifier
R-HSA-6806957
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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MET receptor dimerizes
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Upon ligand binding, MET receptor forms homodimers. Interaction between beta chains of two MET-bound HGF heterodimers may promote dimer formation (Stamos et al. 2004, Gherardi et al. 2006). Ligand bound MET dimers can further oligomerize (Hays and Watowich 2004).

Literature References
PubMed ID Title Journal Year
15301554 Oligomerization-dependent changes in the thermodynamic properties of the TPR-MET receptor tyrosine kinase

Hays, JL, Watowich, SJ

Biochemistry 2004
16537482 Structural basis of hepatocyte growth factor/scatter factor and MET signalling

Gherardi, E, Sandin, S, Petoukhov, MV, Finch, J, Youles, ME, Ofverstedt, LG, Miguel, RN, Blundell, TL, Vande Woude, GF, Skoglund, U, Svergun, DI

Proc. Natl. Acad. Sci. U.S.A. 2006
15167892 Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor

Stamos, J, Lazarus, RA, Yao, X, Kirchhofer, D, Wiesmann, C

EMBO J. 2004
Participants
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Orthologous Events
MET receptor dimerizes (Danio rerio)
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Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Heynen, G  (2016-07-11)
Birchmeier, W  (2016-07-11)
Created
Orlic-Milacic, M  (2015-10-28)