Reactome | MET receptor dimerizes

MET receptor dimerizes

Stable Identifier

R-HSA-6806957

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Upon ligand binding, MET receptor forms homodimers. Interaction between beta chains of two MET-bound HGF heterodimers may promote dimer formation (Stamos et al. 2004, Gherardi et al. 2006). Ligand bound MET dimers can further oligomerize (Hays and Watowich 2004).

Literature References

PubMed ID	Title	Journal	Year
16537482	Structural basis of hepatocyte growth factor/scatter factor and MET signalling Ofverstedt, LG, Sandin, S, Svergun, DI, Finch, J, Miguel, RN, Petoukhov, MV, Vande Woude, GF, Gherardi, E, Skoglund, U, Youles, ME, Blundell, TL	Proc. Natl. Acad. Sci. U.S.A.	2006
15301554	Oligomerization-dependent changes in the thermodynamic properties of the TPR-MET receptor tyrosine kinase Watowich, SJ, Hays, JL	Biochemistry	2004
15167892	Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor Kirchhofer, D, Wiesmann, C, Stamos, J, Yao, X, Lazarus, RA	EMBO J.	2004