Upon ligand binding, MET receptor forms homodimers. Interaction between beta chains of two MET-bound HGF heterodimers may promote dimer formation (Stamos et al. 2004, Gherardi et al. 2006). Ligand bound MET dimers can further oligomerize (Hays and Watowich 2004).
Hays, JL, Watowich, SJ
Gherardi, E, Sandin, S, Petoukhov, MV, Finch, J, Youles, ME, Ofverstedt, LG, Miguel, RN, Blundell, TL, Vande Woude, GF, Skoglund, U, Svergun, DI
Stamos, J, Lazarus, RA, Yao, X, Kirchhofer, D, Wiesmann, C
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