Reactome | HGF dimer binds MET

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HGF dimer binds MET Show undefined attributes

authored	[InstanceEdit:6800310] Jassal, Bijay, 2015-09-29
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:6800310] Jassal, Bijay, 2015-09-29
dbId	6800298
displayName	HGF dimer binds MET
edited	[InstanceEdit:6800310] Jassal, Bijay, 2015-09-29 [InstanceEdit:8931763] Orlic-Milacic, Marija, 2016-07-18
eventOf	[Pathway:R-HSA-6806942] MET Receptor Activation - Homo sapiens
followingEvent	[Reaction:R-HSA-6806957] MET receptor dimerizes - Homo sapiens
input	[Complex:R-HSA-141763] HGF dimer [extracellular region] [EntityWithAccessionedSequence:R-HSA-419603] MET [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6800292] Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor [LiteratureReference:6800295] Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling [LiteratureReference:8875968] Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud [LiteratureReference:8876032] Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene [LiteratureReference:8931765] Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation [LiteratureReference:8875989] Scatter factor/hepatocyte growth factor is essential for liver development [LiteratureReference:8876009] Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas [LiteratureReference:8875991] Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	HGF dimer binds MET
orthologousEvent	[Reaction:R-GGA-6800298] HGF dimer binds MET - Gallus gallus [Reaction:R-XTR-6800298] HGF dimer binds MET - Xenopus tropicalis [Reaction:R-DRE-6800298] HGF dimer binds MET - Danio rerio [Reaction:R-SSC-6800298] HGF dimer binds MET - Sus scrofa [Reaction:R-BTA-6800298] HGF dimer binds MET - Bos taurus [Reaction:R-CFA-6800298] HGF dimer binds MET - Canis familiaris [Reaction:R-RNO-6800298] HGF dimer binds MET - Rattus norvegicus [Reaction:R-MMU-6800298] HGF dimer binds MET - Mus musculus
output	[Complex:R-HSA-6800287] HGF dimer:MET [plasma membrane]
precedingEvent	[Reaction:R-HSA-6800299] HGFAC cleaves pro-HGF to form HGF dimer - Homo sapiens [Reaction:R-HSA-6800200] HPN heterodimer cleaves pro-HGF to form HGF dimer - Homo sapiens
regulatedBy	[NegativeRegulation:9734071] Negative regulation by 'Anti-MET MAbs:MET [plasma membrane]'
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8851787] D'Eustachio, Peter, 2016-01-11 [InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11 [InstanceEdit:9750147] Kadambat Nair, Sisira, 2021-08-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6800298
summation	[Summation:6800313] Hepatocyte growth factor (HGF) is a pleiotropic factor and a...
updateTrackers	[UpdateTracker:9775692] Update Tracker - [Reaction:6800298] HGF dimer binds MET - v78:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9775692] Update Tracker - [Reaction:6800298] HGF dimer binds MET - v78:[addRegulator]
(hasEvent)	[Pathway:R-HSA-6806942] MET Receptor Activation
(precedingEvent)	[Reaction:R-HSA-6806957] MET receptor dimerizes

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