Reactome | MET Receptor Activation

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MET Receptor Activation Show undefined attributes

authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
created	[InstanceEdit:6806943] Orlic-Milacic, Marija, 2015-10-28
dbId	6806942
displayName	MET Receptor Activation
doi	10.3180/R-HSA-6806942.2
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
eventOf	[Pathway:R-HSA-6806834] Signaling by MET - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-6800200] HPN heterodimer cleaves pro-HGF to form HGF dimer - Homo sapiens [Reaction:R-HSA-6800299] HGFAC cleaves pro-HGF to form HGF dimer - Homo sapiens [Reaction:R-HSA-6800298] HGF dimer binds MET - Homo sapiens [Reaction:R-HSA-6806957] MET receptor dimerizes - Homo sapiens [Reaction:R-HSA-6806974] MET dimers autophosphorylate - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:6800314] Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B [LiteratureReference:6800292] Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor [LiteratureReference:6800220] Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2 [LiteratureReference:6800295] Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling [LiteratureReference:6806963] Oligomerization-dependent changes in the thermodynamic properties of the TPR-MET receptor tyrosine kinase [LiteratureReference:6806998] Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase [LiteratureReference:6806987] Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor) [LiteratureReference:6806986] Autophosphorylation modulates the kinase activity and oncogenic potential of the Met receptor tyrosine kinase [LiteratureReference:6806997] A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family [LiteratureReference:8875752] c-Met recruits ICAM-1 as a coreceptor to compensate for the loss of CD44 in Cd44 null mice [LiteratureReference:8875728] Internalization of Met requires the co-receptor CD44v6 and its link to ERM proteins [LiteratureReference:8875745] CD44 is required for two consecutive steps in HGF/c-Met signaling [LiteratureReference:8875749] CD44-independent activation of the Met signaling pathway by HGF and InlB [LiteratureReference:8875742] Activation of c-Met and upregulation of CD44 expression are associated with the metastatic phenotype in the colorectal cancer liver metastasis model [LiteratureReference:8931730] Structural basis of hepatocyte growth factor/scatter factor and MET signalling [LiteratureReference:8931736] Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA
maxDepth	2
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	MET Receptor Activation
orthologousEvent	[Pathway:R-GGA-6806942] MET Receptor Activation - Gallus gallus [Pathway:R-XTR-6806942] MET Receptor Activation - Xenopus tropicalis [Pathway:R-DRE-6806942] MET Receptor Activation - Danio rerio [Pathway:R-SSC-6806942] MET Receptor Activation - Sus scrofa [Pathway:R-BTA-6806942] MET Receptor Activation - Bos taurus [Pathway:R-CFA-6806942] MET Receptor Activation - Canis familiaris [Pathway:R-RNO-6806942] MET Receptor Activation - Rattus norvegicus [Pathway:R-MMU-6806942] MET Receptor Activation - Mus musculus
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11 [InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6806942
summation	[Summation:8875945] Hepatocyte growth factor (HGF), the ligand for MET receptor ...
updateTrackers	[UpdateTracker:9775567] Update Tracker - [Pathway:6806942] MET Receptor Activation - v78:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9775567] Update Tracker - [Pathway:6806942] MET Receptor Activation - v78:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-6806834] Signaling by MET

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