Reactome | Regulation of TP53 Activity

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Regulation of TP53 Activity Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
created	[InstanceEdit:5633006] Orlic-Milacic, Marija, 2014-10-29
dbId	5633007
displayName	Regulation of TP53 Activity
doi	10.3180/r-hsa-5633007.1
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-3700989] Transcriptional Regulation by TP53 - Homo sapiens
figure	[Figure:9628894] /figures/ehld/R-HSA-5633007.svg
goBiologicalProcess	[GO_BiologicalProcess:3132571] regulation of signal transduction by p53 class mediator
hasDiagram	true
hasEHLD	true
hasEvent	[Pathway:R-HSA-6806003] Regulation of TP53 Expression and Degradation - Homo sapiens [Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation - Homo sapiens [Pathway:R-HSA-6804759] Regulation of TP53 Activity through Association with Co-factors - Homo sapiens [Pathway:R-HSA-6804760] Regulation of TP53 Activity through Methylation - Homo sapiens [Pathway:R-HSA-6804758] Regulation of TP53 Activity through Acetylation - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-10-05
literatureReference	[LiteratureReference:6806099] Modes of p53 regulation [LiteratureReference:8856273] Posttranslational modification of p53: cooperative integrators of function [LiteratureReference:8856277] p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1 [LiteratureReference:8856279] Interaction of p53 with prolyl isomerases: Healthy and unhealthy relationships
maxDepth	4
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Regulation of TP53 Activity
orthologousEvent	[Pathway:R-DRE-5633007] Regulation of TP53 Activity - Danio rerio [Pathway:R-PFA-5633007] Regulation of TP53 Activity - Plasmodium falciparum [Pathway:R-DDI-5633007] Regulation of TP53 Activity - Dictyostelium discoideum [Pathway:R-BTA-5633007] Regulation of TP53 Activity - Bos taurus [Pathway:R-MMU-5633007] Regulation of TP53 Activity - Mus musculus [Pathway:R-GGA-5633007] Regulation of TP53 Activity - Gallus gallus [Pathway:R-RNO-5633007] Regulation of TP53 Activity - Rattus norvegicus [Pathway:R-SCE-5633007] Regulation of TP53 Activity - Saccharomyces cerevisiae [Pathway:R-SPO-5633007] Regulation of TP53 Activity - Schizosaccharomyces pombe [Pathway:R-XTR-5633007] Regulation of TP53 Activity - Xenopus tropicalis [Pathway:R-CEL-5633007] Regulation of TP53 Activity - Caenorhabditis elegans [Pathway:R-SSC-5633007] Regulation of TP53 Activity - Sus scrofa [Pathway:R-CFA-5633007] Regulation of TP53 Activity - Canis familiaris [Pathway:R-DME-5633007] Regulation of TP53 Activity - Drosophila melanogaster
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5633007
summation	[Summation:6806095] Protein stability and transcriptional activity of TP53 (p53)...
updateTrackers	[UpdateTracker:9864173] Update Tracker - [Pathway:5633007] Regulation of TP53 Activity - v88:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783247] Update Tracker - [Pathway:5633007] Regulation of TP53 Activity - v57:[updateIndirectRLE] [UpdateTracker:9782842] Update Tracker - [Pathway:5633007] Regulation of TP53 Activity - v58:[updateContainedPathway]

Referrals

(updatedInstance)	[UpdateTracker:9864173] Update Tracker - [Pathway:5633007] Regulation of TP53 Activity - v88:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783247] Update Tracker - [Pathway:5633007] Regulation of TP53 Activity - v57:[updateIndirectRLE] [UpdateTracker:9782842] Update Tracker - [Pathway:5633007] Regulation of TP53 Activity - v58:[updateContainedPathway]
(hasEvent)	[Pathway:R-HSA-3700989] Transcriptional Regulation by TP53
(hasEncapsulatedEvent)	[Pathway:R-HSA-5633008] TP53 Regulates Transcription of Cell Death Genes [Pathway:R-HSA-6791312] TP53 Regulates Transcription of Cell Cycle Genes

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