Reactome | ATM phosphorylates MDM2

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ATM phosphorylates MDM2 Show undefined attributes

catalystActivity	[CatalystActivity:10470234] protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10529825
displayName	ATM phosphorylates MDM2
eventOf	[Pathway:R-SSC-69541] Stabilization of p53 - Sus scrofa [Pathway:R-SSC-6804757] Regulation of TP53 Degradation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6804955] ATM phosphorylates MDM2 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-SSC-6793669] phospho-MDM2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	ATM phosphorylates MDM2
output	4 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-SSC-6804954] phospho-MDM2 [nucleoplasm]
precedingEvent	[Reaction:R-SSC-6793666] MDM2 translocates to the nucleus - Sus scrofa [Reaction:R-SSC-5693540] MRN activates ATM - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-6804955
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-69541] Stabilization of p53 [Pathway:R-SSC-6804757] Regulation of TP53 Degradation
(inferredTo)	[Reaction:R-HSA-6804955] ATM phosphorylates MDM2