Reactome | PCBP4 binds the CDKN1A mRNA

PCBP4 binds the CDKN1A mRNA

Stable Identifier

R-HSA-6803403

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
      - p53-Dependent G1 DNA Damage Response (Homo sapiens)
        
        Transcriptional activation of p53 responsive genes (Homo sapiens)
        
        Transcriptional activation of cell cycle inhibitor p21 (Homo sapiens)
        
        PCBP4 binds the CDKN1A mRNA (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - FOXO-mediated transcription (Homo sapiens)
      - FOXO-mediated transcription of cell cycle genes (Homo sapiens)
        
        PCBP4 binds the CDKN1A mRNA (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)
        
        PCBP4 binds the CDKN1A mRNA (Homo sapiens)

General

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PCBP4 binds the 3'-UTR of the CDKN1A (p21) mRNA and reduces its stability (Scoumanne et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
20817677	The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability Chen, X, Cho, SJ, Scoumanne, A, Zhang, J	Nucleic Acids Res.	2011

Participants

Input

Output

PCBP4:CDKN1A mRNA [cytosol] (Homo sapiens)

Participates

as an event of

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Bertaggia, E (2018-10-26)

Zaccara, S (2016-02-04)

Donlon, T (2018-10-17)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-10-07)

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