Reactome | Dimerization of BRAF V600E splice variants contributes to BRAF inhibitor resistance

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Dimerization of BRAF V600E splice variants contributes to BRAF inhibitor resistance Show undefined attributes

authored	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6802929] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	6802930
disease	[Disease:1500689] cancer
displayName	Dimerization of BRAF V600E splice variants contributes to BRAF inhibitor resistance
edited	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
entityFunctionalStatus	[EntityFunctionalStatus:6802906] gain_of_function of V600E BRAF splice variants [cytosol]
eventOf	[Pathway:R-HSA-6802948] Signaling by high-kinase activity BRAF mutants - Homo sapiens
input	2 × [DefinedSet:R-HSA-6802657] V600E BRAF splice variants [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:6799053] Inhibition of mutated, activated BRAF in metastatic melanoma [LiteratureReference:6799050] Improved survival with vemurafenib in melanoma with BRAF V600E mutation [LiteratureReference:6799066] Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib [LiteratureReference:6790435] Tumor adaptation and resistance to RAF inhibitors [LiteratureReference:6799060] RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E) [LiteratureReference:6799059] Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation [LiteratureReference:6799049] Elucidating distinct roles for NF1 in melanomagenesis [LiteratureReference:6799041] A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition [LiteratureReference:6799057] Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance [LiteratureReference:6799047] Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dimerization of BRAF V600E splice variants contributes to BRAF inhibitor resistance
output	[Complex:R-HSA-6802656] V600E BRAF splice variant dimer [cytosol]
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933498] Stephens, Robert M, 2016-08-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6802930
summation	[Summation:6802234] RAF kinase inhibitors such as vemurafenib are clinically app...

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[Pathway:R-HSA-6802948] Signaling by high-kinase activity BRAF mutants

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