Reactome | BRAF N581S [cytosol]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-HSA-6802641] moderate kinase activity BRAF mutants [cytosol] - Homo sapiens
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9648851] Rothfels, Karen, 2019-06-07
crossReference	[DatabaseIdentifier:12021104] Mondo:0006247 [DatabaseIdentifier:9648847] COSMIC:COSV56058108
dbId	9648850
disease	[Disease:1614289] melanoma [Disease:9648849] histiocytic and dendritic cell cancer [Disease:4791250] colorectal cancer
displayName	BRAF N581S [cytosol]
endCoordinate	766
hasModifiedResidue	[ModifiedResidue:5672668] O-phospho-L-serine at 446 [ModifiedResidue:5672670] O-phospho-L-serine at 729 [ReplacedResidue:9648848] L-asparagine 581 replaced with L-serine
inDisease	true
literatureReference	[LiteratureReference:9648829] Somatic mutations in histiocytic sarcoma identified by next generation sequencing [LiteratureReference:9648762] Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma [LiteratureReference:9648756] Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study
maxDepth	1
name	BRAF N581S B-RAF
referenceEntity	[ReferenceGeneProduct:uniprot:P15056] UniProt:P15056 BRAF
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9648850
startCoordinate	2

(hasCandidate)

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