moderate kinase activity BRAF mutants [cytosol]

Stable Identifier
R-HSA-6802641
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
12068308 Mutations of the BRAF gene in human cancer

Davies, H, Bignell, GR, Cox, C, Stephens, P, Edkins, S, Clegg, S, Teague, J, Woffendin, H, Garnett, MJ, Bottomley, W, Davis, N, Dicks, E, Ewing, R, Floyd, Y, Gray, K, Hall, S, Hawes, R, Hughes, J, Kosmidou, V, Menzies, A, Mould, C, Parker, A, Stevens, C, Watt, S, Hooper, S, Wilson, R, Jayatilake, H, Gusterson, BA, Cooper, C, Shipley, J, Hargrave, D, Pritchard-Jones, K, Maitland, N, Chenevix-Trench, G, Riggins, GJ, Bigner, DD, Palmieri, G, Cossu, A, Flanagan, A, Nicholson, A, Ho, JW, Leung, SY, Yuen, ST, Weber, BL, Seigler, HF, Darrow, TL, Paterson, H, Marais, R, Marshall, CJ, Wooster, R, Stratton, MR, Futreal, PA

Nature 2002
16474404 Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome

Niihori, T, Aoki, Y, Narumi, Y, Neri, G, Cavé, H, Verloes, A, Okamoto, N, Hennekam, RC, Gillessen-Kaesbach, G, Wieczorek, D, Kavamura, MI, Kurosawa, K, Ohashi, H, Wilson, L, Heron, D, Bonneau, D, Corona, G, Kaname, T, Naritomi, K, Baumann, C, Matsumoto, N, Kato, K, Kure, S, Matsubara, Y

Nat. Genet. 2006
15035987 Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

Wan, PT, Garnett, MJ, Roe, SM, Lee, S, Niculescu-Duvaz, D, Good, VM, Jones, CM, Marshall, CJ, Springer, CJ, Barford, D, Marais, R

Cell 2004
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
cardiofaciocutaneous syndrome 0060233 CFC syndrome, cardio-facial-cutaneous syndrome