Cytosolic 5-formyltetrahydrofolate cyclo-ligase (MTHFS) cata...

created [InstanceEdit:6801327] Jassal, Bijay, 2015-10-01
dbId 6801339
displayName Cytosolic 5-formyltetrahydrofolate cyclo-ligase (MTHFS) cata...
modified [InstanceEdit:8849238] Jassal, Bijay, 2015-12-14
schemaClass Summation
text Cytosolic 5-formyltetrahydrofolate cyclo-ligase (MTHFS) catalyses the irreversible transformation of 5-formyltetrahydrofolate (5-formyl-THF) to 5,10-methenyltetrahydrofolate (5,10-methenyl-THF) (Dayan et al. 1995). MTHFS has higher affinity for the polyglutamate form of 5-formyl-THF (5-formyl-THFPG) (Bertrand et al. 1987). This reaction of tetrahydrofolate metabolism helps regulate carbon flow through the folate-dependent one-carbon metabolic network which is essential for growth and proliferation of cells.
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