HGF dimer binds MET

Stable Identifier
Homo sapiens
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Hepatocyte growth factor (HGF) is a pleiotropic factor and activates hepatocyte growth factor receptor (MET). HGF is secreted into the extracellular matrix as an inactive single chain precursor (pro-HGF (32-728)) and requires cleavage to form the biologically active alpha-beta heterodimer. HGF/MET signalling plays an important role in normal development and in tumor growth and metastasis (Rong et al. 1994, Schmidt et al. 1995, Uehara et al. 1995, Bladt et al. 1995, Schmidt et al. 1997, Pennacchietti et al. 2003, Stamos et al. 2004). HGF binds the SEMA and PSI domain of the MET receptor (Kirchhofer et al. 2004).

Literature References
PubMed ID Title Journal Year
9140397 Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

Schmidt, L, Bernues, M, Slife, L, Chen, F, Stackhouse, T, Brauch, H, Dean, M, Zbar, B, Casadevall, C, Linehan, WM, Allikmets, R, Orcutt, ML, Zamarron, A, Zhuang, Z, Kishida, T, Richard, S, Niehans, G, Lipan, J, Chidambaram, A, Geil, L, Feltis, JT, Choyke, P, Bergerheim, UR, Duh, FM, Storkel, S, Tsui, LC, Lubensky, I, Lerman, MI, Scherer, SW, Lips, CJ, Glenn, G, Walther, MM, Moch, H, Hughson, MD, Decker, J

Nat. Genet. 1997
8197126 Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation

Segal, S, Rong, S, Resau, JH, Vande Woude, GF, Anver, M

Proc. Natl. Acad. Sci. U.S.A. 1994
12726861 Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

Mazzone, M, Giordano, S, Galluzzo, M, Comoglio, PM, Pennacchietti, S, Michieli, P

Cancer Cell 2003
7651534 Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

Birchmeier, C, Riethmacher, D, Bladt, F, Aguzzi, A, Isenmann, S

Nature 1995
15167892 Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor

Kirchhofer, D, Wiesmann, C, Stamos, J, Yao, X, Lazarus, RA

EMBO J. 2004
7854452 Scatter factor/hepatocyte growth factor is essential for liver development

Brinkmann, V, Zschiesche, W, Sharpe, M, Birchmeier, C, Gherardi, E, Bladt, F, Schmidt, C, Goedecke, S

Nature 1995
7854453 Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

Mori, C, Kitamura, N, Noda, T, Kuno, J, Minowa, O, Uehara, Y, Shiota, K

Nature 1995
15218027 Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling

Kirchhofer, D, Billeci, KL, Lipari, MT, Wiesmann, C, Yao, X, Santell, L, Maun, HR, Eigenbrot, C, Peek, M, Lazarus, RA, Moran, P

J. Biol. Chem. 2004
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