Reactome | HGF dimer binds MET

Schema > Reaction > Entries

HGF dimer binds MET Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10302928
displayName	HGF dimer binds MET
eventOf	[Pathway:R-CFA-6806942] MET Receptor Activation - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-6806957] MET receptor dimerizes - Canis familiaris
inferredFrom	[Reaction:R-HSA-6800298] HGF dimer binds MET - Homo sapiens
input	[Complex:R-CFA-141763] HGF dimer [extracellular region] [EntityWithAccessionedSequence:R-CFA-419603] MET [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	HGF dimer binds MET
output	[Complex:R-CFA-6800287] HGF dimer:MET [plasma membrane]
precedingEvent	[Reaction:R-CFA-6800299] HGFAC cleaves pro-HGF to form HGF dimer - Canis familiaris [Reaction:R-CFA-6800200] HPN heterodimer cleaves pro-HGF to form HGF dimer - Canis familiaris
regulatedBy	[NegativeRegulation:10302929] Negative regulation by 'Anti-MET MAbs:MET [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-6800298
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-6806942] MET Receptor Activation
(precedingEvent)	[Reaction:R-CFA-6806957] MET receptor dimerizes
(inferredTo)	[Reaction:R-HSA-6800298] HGF dimer binds MET