Reactome | TP53I3 oxidoreductase generates unstable semiquinones

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TP53I3 oxidoreductase generates unstable semiquinones Show undefined attributes

catalystActivity	[CatalystActivity:10302816] quinone reductase (NADPH) activity of TP53I3 Dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10302818
displayName	TP53I3 oxidoreductase generates unstable semiquinones
eventOf	[Pathway:R-CFA-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6799722] TP53I3 oxidoreductase generates unstable semiquinones - Homo sapiens
input	2 × [SimpleEntity:R-ALL-6799725] 1,2-Naphthoquinone [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	TP53I3 oxidoreductase generates unstable semiquinones
output	[SimpleEntity:R-ALL-29366] NADP+ [cytosol] 2 × [SimpleEntity:R-ALL-6799726] semiquinone [cytosol]
precedingEvent	[Reaction:R-CFA-6799466] TP53I3 dimerizes - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-6799722
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
(inferredTo)	[Reaction:R-HSA-6799722] TP53I3 oxidoreductase generates unstable semiquinones

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