| created | [InstanceEdit:6799724] Orlic-Milacic, Marija, 2015-09-25 |
| dbId | 6799727 |
| displayName | TP53I3 (PIG3) possesses a NADPH quinone reductase activity, ... |
| schemaClass | Summation |
| text | TP53I3 (PIG3) possesses a NADPH quinone reductase activity, with 1,2-naphthoquinone being its preferred substrate. TP53I3 reduces 1,2-naphthoquinone to a highly unstable semiquinone free radical. Semiquinone reacts with oxygen yielding a quinone and superoxide aninon. Reactive oxygen species (ROS) produced as a result of TP53I3 activity contribute to apoptosis (Porte et al. 2009). |
| (summation) |
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