Reactome | ATM phosphorylates DYRK2

Schema > Reaction > Entries

ATM phosphorylates DYRK2 Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:5693530] protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6798384] Orlic-Milacic, Marija, 2015-09-18
dbId	6798372
displayName	ATM phosphorylates DYRK2
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation - Homo sapiens
followingEvent	[Reaction:R-HSA-6798374] DYRK2 phosphorylates TP53 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3215037] DYRK2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6798379] ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	ATM phosphorylates DYRK2
orthologousEvent	[Reaction:R-SPO-6798372] ATM phosphorylates DYRK2 - Schizosaccharomyces pombe [Reaction:R-DDI-6798372] ATM phosphorylates DYRK2 - Dictyostelium discoideum [Reaction:R-DME-6798372] ATM phosphorylates DYRK2 - Drosophila melanogaster [Reaction:R-GGA-6798372] ATM phosphorylates DYRK2 - Gallus gallus [Reaction:R-DRE-6798372] ATM phosphorylates DYRK2 - Danio rerio [Reaction:R-SSC-6798372] ATM phosphorylates DYRK2 - Sus scrofa [Reaction:R-BTA-6798372] ATM phosphorylates DYRK2 - Bos taurus [Reaction:R-CFA-6798372] ATM phosphorylates DYRK2 - Canis familiaris [Reaction:R-RNO-6798372] ATM phosphorylates DYRK2 - Rattus norvegicus [Reaction:R-MMU-6798372] ATM phosphorylates DYRK2 - Mus musculus
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6798368] p-T106,S442-DYRK2 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5693540] MRN activates ATM - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6798372
summation	[Summation:6798376] Activated ATM kinase phosphorylates DYRK2 at threonine resid...

Referrals

(hasEvent)	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation
(precedingEvent)	[Reaction:R-HSA-6798374] DYRK2 phosphorylates TP53