Reactome | ATM phosphorylates DYRK2

Schema > Reaction > Entries

ATM phosphorylates DYRK2 Show undefined attributes

catalystActivity	[CatalystActivity:10712903] protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10717530
displayName	ATM phosphorylates DYRK2
eventOf	[Pathway:R-DME-6804756] Regulation of TP53 Activity through Phosphorylation - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-DME-6798374] DYRK2 phosphorylates TP53 - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-6798372] ATM phosphorylates DYRK2 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-DME-3215037] DYRK2 [nucleoplasm]
isInDisease	false
isInferred	true
name	ATM phosphorylates DYRK2
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-DME-6798368] phospho-p-T106,S442-DYRK2 [nucleoplasm]
precedingEvent	[Reaction:R-DME-5693540] MRN activates ATM - Drosophila melanogaster
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-6798372
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-6804756] Regulation of TP53 Activity through Phosphorylation
(precedingEvent)	[Reaction:R-DME-6798374] DYRK2 phosphorylates TP53
(inferredTo)	[Reaction:R-HSA-6798372] ATM phosphorylates DYRK2