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Entries
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes
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authored
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity
[CatalystActivity:6797610] cyclin-dependent protein serine/threonine kinase activity of CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:6797603] Orlic-Milacic, Marija, 2015-09-14
dbId
6797606
displayName
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes
edited
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf
[Pathway:R-HSA-6796648] TP53 Regulates Transcription of DNA Repair Genes - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-6797712] CDK12 stimulates expression of DNA repair genes - Homo sapiens
input
[SimpleEntity:R-ALL-29358] ATP [nucleoplasm]
[Complex:R-HSA-6797614] CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:6797093] The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes
[LiteratureReference:6797666] Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing
[LiteratureReference:6797674] Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex
[LiteratureReference:6797685] Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II
[LiteratureReference:6797694] The structure and substrate specificity of human Cdk12/Cyclin K
modified
[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes
orthologousEvent
[Reaction:R-SCE-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Saccharomyces cerevisiae
[Reaction:R-SPO-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Schizosaccharomyces pombe
[Reaction:R-DDI-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Dictyostelium discoideum
[Reaction:R-CEL-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Caenorhabditis elegans
[Reaction:R-DME-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Drosophila melanogaster
[Reaction:R-GGA-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Gallus gallus
[Reaction:R-XTR-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Xenopus tropicalis
[Reaction:R-DRE-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Danio rerio
[Reaction:R-SSC-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Sus scrofa
[Reaction:R-BTA-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Bos taurus
[Reaction:R-CFA-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Canis familiaris
[Reaction:R-RNO-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Rattus norvegicus
[Reaction:R-MMU-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Mus musculus
output
[SimpleEntity:R-ALL-113582] ADP [nucleoplasm]
[Complex:R-HSA-6797602] CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm]
precedingEvent
[Reaction:R-HSA-6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes - Homo sapiens
releaseDate
2016-03-23
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
[InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-6797606
summation
[Summation:6797681] CDK12, in complex with CCNK (cyclin K), phosphorylates hepta...
Referrals
(precedingEvent)
[BlackBoxEvent:R-HSA-6797712] CDK12 stimulates expression of DNA repair genes
(hasEvent)
[Pathway:R-HSA-6796648] TP53 Regulates Transcription of DNA Repair Genes
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