Reactome | CCNK:CDK12 binds RNA Pol II at DNA repair genes

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CCNK:CDK12 binds RNA Pol II at DNA repair genes Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6797603] Orlic-Milacic, Marija, 2015-09-14
dbId	6797616
displayName	CCNK:CDK12 binds RNA Pol II at DNA repair genes
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6796648] TP53 Regulates Transcription of DNA Repair Genes - Homo sapiens
followingEvent	[Reaction:R-HSA-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Homo sapiens
input	[Complex:R-HSA-6797095] CCNK:CDK12 [nucleoplasm] [Complex:R-HSA-6797611] Elongation Complex at DNA Repair Genes [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6797093] The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes [LiteratureReference:6797658] Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex [LiteratureReference:6797674] Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex [LiteratureReference:6797666] Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	CCNK:CDK12 binds RNA Pol II at DNA repair genes
orthologousEvent	[Reaction:R-SCE-6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes - Saccharomyces cerevisiae [Reaction:R-SPO-6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes - Schizosaccharomyces pombe [Reaction:R-DDI-6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes - Dictyostelium discoideum [Reaction:R-CEL-6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes - Caenorhabditis elegans [Reaction:R-DME-6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes - Drosophila melanogaster [Reaction:R-GGA-6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes - Gallus gallus [Reaction:R-XTR-6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes - Xenopus tropicalis [Reaction:R-SSC-6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes - Sus scrofa [Reaction:R-BTA-6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes - Bos taurus [Reaction:R-CFA-6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes - Canis familiaris [Reaction:R-RNO-6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes - Rattus norvegicus [Reaction:R-MMU-6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes - Mus musculus
output	[Complex:R-HSA-6797614] CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6797090] CCNK binds CDK12 - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6797616
summation	[Summation:6797670] The complex of CDK12 and CCNK (cyclin K) associates with the...

Referrals

(hasEvent)	[Pathway:R-HSA-6796648] TP53 Regulates Transcription of DNA Repair Genes
(precedingEvent)	[Reaction:R-HSA-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes

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