Reactome | TP53 Regulates Transcription of DNA Repair Genes

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TP53 Regulates Transcription of DNA Repair Genes Show undefined attributes

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10730972
displayName	TP53 Regulates Transcription of DNA Repair Genes
eventOf	[Pathway:R-XTR-3700989] Transcriptional Regulation by TP53 - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-XTR-6797090] CCNK binds CDK12 - Xenopus tropicalis [Reaction:R-XTR-6797100] CCNK binds CDK13 - Xenopus tropicalis [Reaction:R-XTR-6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes - Xenopus tropicalis [Reaction:R-XTR-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-6796648] TP53 Regulates Transcription of DNA Repair Genes - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	TP53 Regulates Transcription of DNA Repair Genes
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-6796648
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-3700989] Transcriptional Regulation by TP53
(inferredTo)	[Pathway:R-HSA-6796648] TP53 Regulates Transcription of DNA Repair Genes

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