Reactome | IL13:IL13RA:TYK2 binds IL4R:JAK2

Schema > Reaction > Entries

IL13:IL13RA:TYK2 binds IL4R:JAK2 Show undefined attributes

authored	[InstanceEdit:6785864] Jupe, Steve, 2015-07-01
category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:6786052] Jupe, Steve, 2015-07-03
dbId	6786114
displayName	IL13:IL13RA:TYK2 binds IL4R:JAK2
edited	[InstanceEdit:8937485] Jupe, Steve, 2016-09-02
eventOf	[Pathway:R-HSA-6785807] Interleukin-4 and Interleukin-13 signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-6786110] JAK1 binds IL4R in IL13-bound IL13R type II - Homo sapiens
input	[Complex:R-HSA-6786060] IL13:IL13RA:TYK2 [plasma membrane] [Complex:R-HSA-6785800] IL4R:JAK2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:449676] Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	IL13:IL13RA:TYK2 binds IL4R:JAK2
orthologousEvent	[Reaction:R-SSC-6786114] IL13:IL13RA:TYK2 binds IL4R:JAK2 - Sus scrofa [Reaction:R-BTA-6786114] IL13:IL13RA:TYK2 binds IL4R:JAK2 - Bos taurus [Reaction:R-CFA-6786114] IL13:IL13RA:TYK2 binds IL4R:JAK2 - Canis familiaris [Reaction:R-RNO-6786114] IL13:IL13RA:TYK2 binds IL4R:JAK2 - Rattus norvegicus [Reaction:R-MMU-6786114] IL13:IL13RA:TYK2 binds IL4R:JAK2 - Mus musculus
output	[Complex:R-HSA-6786083] IL13:IL13RA:TYK2:IL4R:JAK2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-6786118] IL13 binds IL13RA:TYK2 - Homo sapiens [Reaction:R-HSA-6785898] IL4R binds JAK2 - Homo sapiens
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8937491] Leibovich, Samuel, 2016-09-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6786114
summation	[Summation:6788349] Interleukin-13 receptor alpha subunit (IL13RA1) binds Interl...

Referrals

(hasEvent)	[Pathway:R-HSA-6785807] Interleukin-4 and Interleukin-13 signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-6786110] JAK1 binds IL4R in IL13-bound IL13R type II

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