Reactome | IL13:IL13RA:TYK2 binds IL4R:JAK2

Schema > Reaction > Entries

IL13:IL13RA:TYK2 binds IL4R:JAK2 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10188964
displayName	IL13:IL13RA:TYK2 binds IL4R:JAK2
eventOf	[Pathway:R-RNO-6785807] Interleukin-4 and Interleukin-13 signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-6786110] JAK1 binds IL4R in IL13-bound IL13R type II - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-6786114] IL13:IL13RA:TYK2 binds IL4R:JAK2 - Homo sapiens
input	[Complex:R-RNO-6786060] IL13:IL13RA:TYK2 [plasma membrane] [Complex:R-RNO-6785800] IL4R:JAK2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IL13:IL13RA:TYK2 binds IL4R:JAK2
output	[Complex:R-RNO-6786083] IL13:IL13RA:TYK2:IL4R:JAK2 [plasma membrane]
precedingEvent	[Reaction:R-RNO-6786118] IL13 binds IL13RA:TYK2 - Rattus norvegicus [Reaction:R-RNO-6785898] IL4R binds JAK2 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6786114
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-6785807] Interleukin-4 and Interleukin-13 signaling
(precedingEvent)	[BlackBoxEvent:R-RNO-6786110] JAK1 binds IL4R in IL13-bound IL13R type II
(inferredTo)	[Reaction:R-HSA-6786114] IL13:IL13RA:TYK2 binds IL4R:JAK2