IL13:IL13RA:TYK2 binds IL4R:JAK2

Stable Identifier
R-HSA-6786114
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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IL13:IL13RA:TYK2 binds IL4R:JAK2
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Interleukin-13 receptor alpha subunit (IL13RA1) binds Interleukin-13 (IL13) with a relatively low affinity, but when paired with Interleukin-4 receptor subunit alpha (IL4R), binds with much higher affinity (Kd = 400 pmol/L) and forms a functional IL13 receptor that is capable of signaling (Miloux et al. 1997). This type II IL13 receptor complex is also the alternative type II receptor for IL4.
Literature References
PubMed ID Title Journal Year
9013879 Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex

Lupker, J, Laurent, P, Vita, N, Miloux, B, Bonnin, O, Caput, D, Ferrara, P

FEBS Lett 1997
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Orthologous Events
IL13:IL13RA:TYK2 binds IL4R:JAK2 (Bos taurus)
IL13:IL13RA:TYK2 binds IL4R:JAK2 (Canis familiaris)
IL13:IL13RA:TYK2 binds IL4R:JAK2 (Mus musculus)
IL13:IL13RA:TYK2 binds IL4R:JAK2 (Rattus norvegicus)
IL13:IL13RA:TYK2 binds IL4R:JAK2 (Sus scrofa)
Authored
Jupe, S  (2015-07-01)
Reviewed
Leibovich, SJ  (2016-09-02)
Created
Jupe, S  (2015-07-03)
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