Reactome | Interleukin-4 and Interleukin-13 signaling

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Interleukin-4 and Interleukin-13 signaling Show undefined attributes

authored	[InstanceEdit:6785864] Jupe, Steve, 2015-07-01
created	[InstanceEdit:6785864] Jupe, Steve, 2015-07-01
crossReference	[DatabaseIdentifier:12819655] BioModels Database:BIOMD0000000314 [DatabaseIdentifier:12819657] BioModels Database:BIOMD0000000313
dbId	6785807
displayName	Interleukin-4 and Interleukin-13 signaling
doi	10.3180/R-HSA-6785807.1
edited	[InstanceEdit:8937485] Jupe, Steve, 2016-09-02
eventOf	[Pathway:R-HSA-449147] Signaling by Interleukins - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:8651] cytokine-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-6785898] IL4R binds JAK2 - Homo sapiens [Reaction:R-HSA-451895] IL2RG binds JAK3 - Homo sapiens [Reaction:R-HSA-9679028] JAK3 binds JAK3 inhibitors - Homo sapiens [Reaction:R-HSA-6785762] IL13RA1 binds TYK2 - Homo sapiens [Reaction:R-HSA-6786101] IL4 binds IL4R:JAK2 - Homo sapiens [Reaction:R-HSA-6786092] IL4:IL4R:JAK2 binds IL2RG:JAK3 - Homo sapiens [Reaction:R-HSA-6786070] IL4:IL4R:JAK2 binds IL13RA1:TYK2 - Homo sapiens [BlackBoxEvent:R-HSA-6786058] JAK1 binds IL4R in IL4-bound IL4R1 - Homo sapiens [BlackBoxEvent:R-HSA-6786096] IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated - Homo sapiens [Reaction:R-HSA-6786124] STAT3,STAT6 bind p-Y-IL4R - Homo sapiens [Reaction:R-HSA-6786095] JAK1 phosphorylates STAT3,STAT6 - Homo sapiens [BlackBoxEvent:R-HSA-6786072] p-Y705-STAT3,p-Y641-STAT6 dissociate - Homo sapiens [BlackBoxEvent:R-HSA-6786097] p-Y705-STAT3, p-Y641-STAT6 dimerise - Homo sapiens [BlackBoxEvent:R-HSA-6786293] p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus - Homo sapiens [BlackBoxEvent:R-HSA-6785860] Expression of SOCS1 - Homo sapiens [BlackBoxEvent:R-HSA-6793975] Expression of GATA3 - Homo sapiens [BlackBoxEvent:R-HSA-6793978] Expression of STAT6-upregulated extracellular proteins - Homo sapiens [BlackBoxEvent:R-HSA-6793958] Expression of STAT6-upregulated plasma membrane proteins - Homo sapiens [BlackBoxEvent:R-HSA-6789615] Expression of STAT3-upregulated extracellular proteins - Homo sapiens [BlackBoxEvent:R-HSA-6790022] Expression of STAT3-upregulated plasma membrane proteins - Homo sapiens [BlackBoxEvent:R-HSA-6790041] Expression of STAT3-upregulated cytosolic proteins - Homo sapiens [BlackBoxEvent:R-HSA-6790036] Expression of STAT3-upregulated nuclear proteins - Homo sapiens [BlackBoxEvent:R-HSA-6790025] Expression of BCL2, BCL2L1 - Homo sapiens [BlackBoxEvent:R-HSA-6790038] Expression of HSP90B1 - Homo sapiens [BlackBoxEvent:R-HSA-6790029] Expression of PTGS2 - Homo sapiens [BlackBoxEvent:R-HSA-6789960] Expression of NDN,TP53 - Homo sapiens [BlackBoxEvent:R-HSA-6797245] Expression of FASLG - Homo sapiens [Reaction:R-HSA-6785821] SOCS5,(SOCS1) bind IL4RA - Homo sapiens [Reaction:R-HSA-449818] IL13 binds IL13RA2 - Homo sapiens [Reaction:R-HSA-6786118] IL13 binds IL13RA:TYK2 - Homo sapiens [Reaction:R-HSA-6786114] IL13:IL13RA:TYK2 binds IL4R:JAK2 - Homo sapiens [BlackBoxEvent:R-HSA-6786110] JAK1 binds IL4R in IL13-bound IL13R type II - Homo sapiens [BlackBoxEvent:R-HSA-6786050] IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated - Homo sapiens [Reaction:R-HSA-6788571] STAT1,STAT3,STAT6 bind IL13:IL13R type II - Homo sapiens [Reaction:R-HSA-6788582] STAT1,STAT3,STAT6 phosphorylation - Homo sapiens [BlackBoxEvent:R-HSA-6788628] p-Y-STATs dissociate - Homo sapiens [BlackBoxEvent:R-HSA-6788622] p-Y-STATs dimerize - Homo sapiens [BlackBoxEvent:R-HSA-6788623] p-Y-STATs translocate to nucleus - Homo sapiens [BlackBoxEvent:R-HSA-6785895] Expression of IL4, IL13-upregulated extracellular proteins - Homo sapiens [BlackBoxEvent:R-HSA-6797269] Expression of HSPA8, ALOX15 - Homo sapiens [BlackBoxEvent:R-HSA-6797267] Expression of CD36 - Homo sapiens [BlackBoxEvent:R-HSA-6797268] Expression of HMOX1 - Homo sapiens [BlackBoxEvent:R-HSA-6797271] Expression of MAOA - Homo sapiens [BlackBoxEvent:R-HSA-6789524] Expression of IL4,IL13-downregulated extracellular genes - Homo sapiens [BlackBoxEvent:R-HSA-6797293] Expression of IL18, ALOX5 - Homo sapiens [BlackBoxEvent:R-HSA-6788346] Expression of IL13-upregulated plasma membrane proteins - Homo sapiens [BlackBoxEvent:R-HSA-6789325] Expression of IL13-downregulated extracellular proteins - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:6785753] The IL-4 receptor: signaling mechanisms and biologic functions [LiteratureReference:6788334] IL-13 receptors and signaling pathways: an evolving web
maxDepth	2
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Interleukin-4 and Interleukin-13 signaling
orthologousEvent	[Pathway:R-DDI-6785807] Interleukin-4 and Interleukin-13 signaling - Dictyostelium discoideum [Pathway:R-CEL-6785807] Interleukin-4 and Interleukin-13 signaling - Caenorhabditis elegans [Pathway:R-DME-6785807] Interleukin-4 and Interleukin-13 signaling - Drosophila melanogaster [Pathway:R-GGA-6785807] Interleukin-4 and Interleukin-13 signaling - Gallus gallus [Pathway:R-XTR-6785807] Interleukin-4 and Interleukin-13 signaling - Xenopus tropicalis [Pathway:R-DRE-6785807] Interleukin-4 and Interleukin-13 signaling - Danio rerio [Pathway:R-SSC-6785807] Interleukin-4 and Interleukin-13 signaling - Sus scrofa [Pathway:R-BTA-6785807] Interleukin-4 and Interleukin-13 signaling - Bos taurus [Pathway:R-CFA-6785807] Interleukin-4 and Interleukin-13 signaling - Canis familiaris [Pathway:R-RNO-6785807] Interleukin-4 and Interleukin-13 signaling - Rattus norvegicus [Pathway:R-MMU-6785807] Interleukin-4 and Interleukin-13 signaling - Mus musculus
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8937491] Leibovich, Samuel, 2016-09-02
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6785807
summation	[Summation:6785855] Interleukin-4 (IL4) is a principal regulatory cytokine durin...
updateTrackers	[UpdateTracker:9780047] Update Tracker - [Pathway:6785807] Interleukin-4 and Interleukin-13 signaling - v64:[updateContainedRLE] [UpdateTracker:9779642] Update Tracker - [Pathway:6785807] Interleukin-4 and Interleukin-13 signaling - v65:[updateContainedRLE] [UpdateTracker:9780262] Update Tracker - [Pathway:6785807] Interleukin-4 and Interleukin-13 signaling - v63:[updateContainedRLE] [UpdateTracker:9780663] Update Tracker - [Pathway:6785807] Interleukin-4 and Interleukin-13 signaling - v62:[updateContainedRLE] [UpdateTracker:9776327] Update Tracker - [Pathway:6785807] Interleukin-4 and Interleukin-13 signaling - v76:[updateContainedRLE] [UpdateTracker:9781141] Update Tracker - [Pathway:6785807] Interleukin-4 and Interleukin-13 signaling - v61:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9776656] Update Tracker - [Pathway:6785807] Interleukin-4 and Interleukin-13 signaling - v74:[addHasEvent, updateContainedRLE] [UpdateTracker:9775925] Update Tracker - [Pathway:6785807] Interleukin-4 and Interleukin-13 signaling - v78:[updateContainedRLE]

Referrals

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[Pathway:R-HSA-449147] Signaling by Interleukins

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