Reactome | UGT8 transfers Gal from UDP-Gal to CERA

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UGT8 transfers Gal from UDP-Gal to CERA Show undefined attributes

catalystActivity	[CatalystActivity:10885719] N-acylsphingosine galactosyltransferase activity of UGT8 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10885721
displayName	UGT8 transfers Gal from UDP-Gal to CERA
eventOf	[Pathway:R-DME-9840309] Glycosphingolipid biosynthesis - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DME-9844955] CLN3 transports GalCer to plasma membrane - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-6785933] UGT8 transfers Gal from UDP-Gal to CERA - Homo sapiens
input	[SimpleEntity:R-ALL-428256] CERA [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1981137] UDP-Gal [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	UGT8 transfers Gal from UDP-Gal to CERA
output	[SimpleEntity:R-ALL-6785915] GalCer [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-158602] UDP [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-DME-1861788] GBA2 hydrolyzes GlcCer (plasma membrane) - Drosophila melanogaster [Reaction:R-DME-1606273] SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-6785933
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[BlackBoxEvent:R-DME-9844955] CLN3 transports GalCer to plasma membrane
(hasEvent)	[Pathway:R-DME-9840309] Glycosphingolipid biosynthesis
(inferredTo)	[Reaction:R-HSA-6785933] UGT8 transfers Gal from UDP-Gal to CERA