Reactome | Interleukin-4 and Interleukin-13 signaling

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Interleukin-4 and Interleukin-13 signaling Show undefined attributes

created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10827927
displayName	Interleukin-4 and Interleukin-13 signaling
eventOf	[Pathway:R-GGA-449147] Signaling by Interleukins - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8651] cytokine-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-GGA-6785898] IL4R binds JAK2 - Gallus gallus [Reaction:R-GGA-9679028] JAK3 binds JAK3 inhibitors - Gallus gallus [Reaction:R-GGA-6786101] IL4 binds IL4R:JAK2 - Gallus gallus [BlackBoxEvent:R-GGA-6786058] JAK1 binds IL4R in IL4-bound IL4R1 - Gallus gallus [BlackBoxEvent:R-GGA-6786096] IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated - Gallus gallus [Reaction:R-GGA-6786124] STAT3,STAT6 bind p-Y-IL4R - Gallus gallus [Reaction:R-GGA-6786095] JAK1 phosphorylates STAT3,STAT6 - Gallus gallus [BlackBoxEvent:R-GGA-6786072] p-Y705-STAT3,p-Y641-STAT6 dissociate - Gallus gallus [BlackBoxEvent:R-GGA-6786097] p-Y705-STAT3, p-Y641-STAT6 dimerise - Gallus gallus [BlackBoxEvent:R-GGA-6786293] p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus - Gallus gallus [BlackBoxEvent:R-GGA-6790038] Expression of HSP90B1 - Gallus gallus [Reaction:R-GGA-6785821] SOCS5,(SOCS1) bind IL4RA - Gallus gallus [BlackBoxEvent:R-GGA-6788622] p-Y-STATs dimerize - Gallus gallus [BlackBoxEvent:R-GGA-6788623] p-Y-STATs translocate to nucleus - Gallus gallus
inferredFrom	[Pathway:R-HSA-6785807] Interleukin-4 and Interleukin-13 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Interleukin-4 and Interleukin-13 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-6785807
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-449147] Signaling by Interleukins
(inferredTo)	[Pathway:R-HSA-6785807] Interleukin-4 and Interleukin-13 signaling

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