Reactome | Interleukin-4 and Interleukin-13 signaling

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Interleukin-4 and Interleukin-13 signaling Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10100379
displayName	Interleukin-4 and Interleukin-13 signaling
eventOf	[Pathway:R-MMU-449147] Signaling by Interleukins - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8651] cytokine-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-6785898] IL4R binds JAK2 - Mus musculus [Reaction:R-MMU-451895] IL2RG binds JAK3 - Mus musculus [Reaction:R-MMU-9679028] JAK3 binds JAK3 inhibitors - Mus musculus [Reaction:R-MMU-6785762] IL13RA1 binds TYK2 - Mus musculus [Reaction:R-MMU-6786101] IL4 binds IL4R:JAK2 - Mus musculus [Reaction:R-MMU-6786092] IL4:IL4R:JAK2 binds IL2RG:JAK3 - Mus musculus [Reaction:R-MMU-6786070] IL4:IL4R:JAK2 binds IL13RA1:TYK2 - Mus musculus [BlackBoxEvent:R-MMU-6786058] JAK1 binds IL4R in IL4-bound IL4R1 - Mus musculus [BlackBoxEvent:R-MMU-6786096] IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated - Mus musculus [Reaction:R-MMU-6786124] STAT3,STAT6 bind p-Y-IL4R - Mus musculus [Reaction:R-MMU-6786095] JAK1 phosphorylates STAT3,STAT6 - Mus musculus [BlackBoxEvent:R-MMU-6786072] p-Y705-STAT3,p-Y641-STAT6 dissociate - Mus musculus [BlackBoxEvent:R-MMU-6786097] p-Y705-STAT3, p-Y641-STAT6 dimerise - Mus musculus [BlackBoxEvent:R-MMU-6786293] p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus - Mus musculus [BlackBoxEvent:R-MMU-6790038] Expression of HSP90B1 - Mus musculus [Reaction:R-MMU-6785821] SOCS5,(SOCS1) bind IL4RA - Mus musculus [Reaction:R-MMU-449818] IL13 binds IL13RA2 - Mus musculus [Reaction:R-MMU-6786118] IL13 binds IL13RA:TYK2 - Mus musculus [Reaction:R-MMU-6786114] IL13:IL13RA:TYK2 binds IL4R:JAK2 - Mus musculus [BlackBoxEvent:R-MMU-6786110] JAK1 binds IL4R in IL13-bound IL13R type II - Mus musculus [BlackBoxEvent:R-MMU-6786050] IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated - Mus musculus [Reaction:R-MMU-6788571] STAT1,STAT3,STAT6 bind IL13:IL13R type II - Mus musculus [Reaction:R-MMU-6788582] STAT1,STAT3,STAT6 phosphorylation - Mus musculus [BlackBoxEvent:R-MMU-6788628] p-Y-STATs dissociate - Mus musculus [BlackBoxEvent:R-MMU-6788622] p-Y-STATs dimerize - Mus musculus [BlackBoxEvent:R-MMU-6788623] p-Y-STATs translocate to nucleus - Mus musculus
inferredFrom	[Pathway:R-HSA-6785807] Interleukin-4 and Interleukin-13 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Interleukin-4 and Interleukin-13 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-6785807
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-449147] Signaling by Interleukins
(inferredTo)	[Pathway:R-HSA-6785807] Interleukin-4 and Interleukin-13 signaling

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