Reactome | tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol

Schema > Reaction > Entries

tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol Show undefined attributes

authored	[InstanceEdit:6783442] May, Bruce, 2015-06-15
catalystActivity	[CatalystActivity:450099] structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope]
catalystActivityReference	[CatalystActivityReference:9643944] structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope] Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase
category	transition
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm [Compartment:13231] nuclear envelope
created	[InstanceEdit:6783459] May, Bruce, 2015-06-15
dbId	6783483
displayName	tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol
edited	[InstanceEdit:6783442] May, Bruce, 2015-06-15
eventOf	[Pathway:R-HSA-6784531] tRNA processing in the nucleus - Homo sapiens
followingEvent	[Reaction:R-HSA-6782296] DUS2:EPRS reduces uridine to dihydrouridine in tRNAs - Homo sapiens [Reaction:R-HSA-6784462] TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs - Homo sapiens [Reaction:R-HSA-6786500] ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34 - Homo sapiens [Reaction:R-HSA-6786501] TRMT11:TRMT112 methylates guanosine-10 in tRNA - Homo sapiens [Reaction:R-HSA-6782264] CTU1:CTU2:URM1 thiolates uridine-34 in tRNAs - Homo sapiens [Reaction:R-HSA-6782443] QTRT1:QTRTD1 exchanges guanine for queuine at guanosine-34 of tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr) yielding queuosine-34 tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr) - Homo sapiens [Reaction:R-HSA-6782434] THG1L transfers GMP to 5' end of tRNA(His) - Homo sapiens [Reaction:R-HSA-6788707] TRMT44 2'-O-methylates uridine-44 in tRNA(Ser) - Homo sapiens [BlackBoxEvent:R-HSA-6786571] CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37 - Homo sapiens [Reaction:R-HSA-8932765] NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:18494] tRNA export from nucleus
input	[Complex:R-HSA-6783450] tRNA:XPOT:RAN:GTP [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6783498] Identification of a tRNA-specific nuclear export receptor [LiteratureReference:6783509] Identification of a nuclear export receptor for tRNA [LiteratureReference:6783504] Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains [LiteratureReference:6783472] Interaction of immobilized human exportin-t with calf liver tRNA [LiteratureReference:6784571] Exportin t and Exportin 5: tRNA and miRNA biogenesis - and beyond
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [DefinedSet:R-HSA-6785476] processed tRNA [cytosol] [Complex:R-HSA-206617] RAN:GDP [cytosol] [EntityWithAccessionedSequence:R-HSA-6783484] XPOT [cytosol]
precedingEvent	[Reaction:R-HSA-6785478] Processed tRNA binds XPOT and RAN:GTP - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790491] Levinger, Louis, 2015-08-10 [InstanceEdit:6792690] Motorin, Yuri, 2015-08-25 [InstanceEdit:6806693] Jarrous, Nayef, 2015-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6783483
summation	[Summation:6784549] The nuclear export receptor XPOT (Exportin-t) interacts with...

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[Pathway:R-HSA-6784531] tRNA processing in the nucleus

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