Reactome | CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37

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CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37 Show undefined attributes

authored	[InstanceEdit:6785729] May, Bruce, 2015-06-30
catalystActivity	[CatalystActivity:6786520] tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity of CDKAL1:4Fe-4S [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9643474] N6-threonylcarbomyladenosine methylthiotransferase activity of CDKAL1:4Fe-4S [endoplasmic reticulum membrane] Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:6786517] May, Bruce, 2015-07-09
dbId	6786571
displayName	CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37
edited	[InstanceEdit:6785729] May, Bruce, 2015-06-30
eventOf	[Pathway:R-HSA-6782315] tRNA modification in the nucleus and cytosol - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:18477] tRNA modification
input	[SimpleEntity:R-ALL-71284] AdoMet [cytosol] [GenomeEncodedEntity:R-HSA-6786554] tRNA containing threonylcarbamoylA-37 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6786534] Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA [LiteratureReference:6790214] CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37
output	[SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [GenomeEncodedEntity:R-HSA-6786533] tRNA containing 2-methylthio-N6-threonylcarbamoylA-37 [cytosol]
precedingEvent	[Reaction:R-HSA-6784494] KEOPS (EKC) complex threonylcarbamoylates A37 of tRNAs - Homo sapiens [Reaction:R-HSA-6783483] tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790491] Levinger, Louis, 2015-08-10 [InstanceEdit:6792690] Motorin, Yuri, 2015-08-25 [InstanceEdit:6806693] Jarrous, Nayef, 2015-10-24
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6786571
summation	[Summation:6786592] The CDKAL1:4Fe-4S complex methylthiolates N6-threonylcarbam...

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(hasEvent)

[Pathway:R-HSA-6782315] tRNA modification in the nucleus and cytosol

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