Reactome | ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34

Schema > Reaction > Entries

ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34 Show undefined attributes

authored	[InstanceEdit:6785729] May, Bruce, 2015-06-30
catalystActivity	[CatalystActivity:6786507] tRNA methyltransferase activity of ALKBH8:Fe2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6786517] May, Bruce, 2015-07-09
dbId	6786500
displayName	ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34
edited	[InstanceEdit:6785729] May, Bruce, 2015-06-30
eventOf	[Pathway:R-HSA-6782315] tRNA modification in the nucleus and cytosol - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:18477] tRNA modification
inferredFrom	[Reaction:R-SCE-6790171] TRM9 methylates 5-carboxymethyluridine-34 in tRNA(Arg3) yielding 5-methoxycarbonylmethyluridine-34 - Saccharomyces cerevisiae
input	[SimpleEntity:R-ALL-71284] AdoMet [cytosol] [DefinedSet:R-HSA-6786556] tRNA(Arg,Glu) containing 5-carboxymethylU-34 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:6786574] Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding [LiteratureReference:6786568] Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34
output	[SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [DefinedSet:R-HSA-6786617] tRNA(Arg,Glu) containing 5-methoxycarbonylmethylU-34 [cytosol]
precedingEvent	[Reaction:R-HSA-6783483] tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790491] Levinger, Louis, 2015-08-10 [InstanceEdit:6792690] Motorin, Yuri, 2015-08-25 [InstanceEdit:6806693] Jarrous, Nayef, 2015-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6786500
summation	[Summation:6786508] ALKBH8:Fe2+ transfers a methyl group from S-adenosylmethioni...

Referrals

(hasEvent)	[Pathway:R-HSA-6782315] tRNA modification in the nucleus and cytosol
(inferredTo)	[Reaction:R-SCE-6790171] TRM9 methylates 5-carboxymethyluridine-34 in tRNA(Arg3) yielding 5-methoxycarbonylmethyluridine-34

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