Reactome | 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER

5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER

Stable Identifier

R-HSA-6782204

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

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5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER

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In transcription-coupled nucleotide excision repair (TC-NER), just like in global genome nucleotide excision repair (GG-NER), the cleavage of the damaged strand of DNA 5' to the site of damage occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The 5' incision is carried out by ERCC1:XPF (ERCC1:ERCC4) complex and precedes the 3' incision by ERCC5 (XPG) (Staresincic et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19279666	Coordination of dual incision and repair synthesis in human nucleotide excision repair Staresincic, L, Fagbemi, AF, Enzlin, JH, Gourdin, AM, Wijgers, N, Dunand-Sauthier, I, Giglia-Mari, G, Clarkson, SG, Vermeulen, W, Schärer, OD	EMBO J.	2009