5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER

Stable Identifier
R-HSA-6782204
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
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In transcription-coupled nucleotide excision repair (TC-NER), just like in global genome nucleotide excision repair (GG-NER), the cleavage of the damaged strand of DNA 5' to the site of damage occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The 5' incision is carried out by ERCC1:XPF (ERCC1:ERCC4) complex and precedes the 3' incision by ERCC5 (XPG) (Staresincic et al. 2009).

Literature References
PubMed ID Title Journal Year
19279666 Coordination of dual incision and repair synthesis in human nucleotide excision repair

Wijgers, N, Staresincic, L, Schärer, OD, Gourdin, AM, Fagbemi, AF, Enzlin, JH, Dunand-Sauthier, I, Clarkson, SG, Giglia-Mari, G, Vermeulen, W

EMBO J. 2009
Participants
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Output
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as an event of
Catalyst Activity

endodeoxyribonuclease activity of TC-NER incision complex [nucleoplasm]

Physical Entity
TC-NER incision complex [nucleoplasm] (Homo sapiens)
Activity
endodeoxyribonuclease activity (GO:0004520)
Orthologous Events
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Bos taurus)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Caenorhabditis elegans)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Canis familiaris)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Danio rerio)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Dictyostelium discoideum)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Drosophila melanogaster)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Gallus gallus)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Mus musculus)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Rattus norvegicus)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Schizosaccharomyces pombe)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Sus scrofa)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-06-16)
Hoeijmakers, JH  (2004-01-29)
Reviewed
Fousteri, M  (2015-08-03)
Created
Orlic-Milacic, M  (2015-06-05)
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