Reactome | Formation of TC-NER Pre-Incision Complex

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Formation of TC-NER Pre-Incision Complex Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10331345
displayName	Formation of TC-NER Pre-Incision Complex
eventOf	[Pathway:R-CFA-6781827] Transcription-Coupled Nucleotide Excision Repair (TC-NER) - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-CFA-6782135] Dual incision in TC-NER - Canis familiaris
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-CFA-6781818] RNA Pol II initiates transcription from damaged DNA template - Canis familiaris [BlackBoxEvent:R-CFA-6781824] Active RNA Pol II complex transcribes lesion-containing DNA template - Canis familiaris [Reaction:R-CFA-6781840] ERCC6 binds stalled RNA Pol II - Canis familiaris [Reaction:R-CFA-6781833] ERCC8 (CSA) binds stalled RNA Pol II - Canis familiaris [Reaction:R-CFA-6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II - Canis familiaris [Reaction:R-CFA-6782004] Assembly of the pre-incision complex in TC-NER - Canis familiaris [Reaction:R-CFA-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Canis familiaris
inferredFrom	[Pathway:R-HSA-6781823] Formation of TC-NER Pre-Incision Complex - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Formation of TC-NER Pre-Incision Complex
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-6781823
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-6781827] Transcription-Coupled Nucleotide Excision Repair (TC-NER)
(precedingEvent)	[Pathway:R-CFA-6782135] Dual incision in TC-NER
(inferredTo)	[Pathway:R-HSA-6781823] Formation of TC-NER Pre-Incision Complex