Reactome | MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF

Schema > Reaction > Entries

MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF Show undefined attributes

catalystActivity	[CatalystActivity:10620345] formate-tetrahydrofolate ligase activity of MTHFD1L dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10620347
displayName	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF
eventOf	[Pathway:R-DRE-196757] Metabolism of folate and pterines - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF - Danio rerio
inferredFrom	[Reaction:R-HSA-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF - Homo sapiens
input	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-6801451] HCOOH [mitochondrial matrix] [SimpleEntity:R-ALL-200671] THF [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF
output	[SimpleEntity:R-ALL-5389850] 10-formyl-THF [mitochondrial matrix] [SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5696839
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-DRE-6801328] MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF
(inferredTo)	[Reaction:R-HSA-5696839] MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF

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