Reactome | ATM phosphorylates TP53 at S15

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ATM phosphorylates TP53 at S15 Show undefined attributes

catalystActivity	[CatalystActivity:10882376] protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10883804
displayName	ATM phosphorylates TP53 at S15
eventOf	[Pathway:R-DME-6804756] Regulation of TP53 Activity through Phosphorylation - Drosophila melanogaster [Pathway:R-DME-2559586] DNA Damage/Telomere Stress Induced Senescence - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-6799246] CHEK1 phosphorylates TP53 - Drosophila melanogaster [Reaction:R-DME-69685] CHEK2 phosphorylates TP53 - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-5693609] ATM phosphorylates TP53 at S15 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-DME-3209194] TP53 Tetramer [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	ATM phosphorylates TP53 at S15
output	4 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-DME-349474] p-S15-TP53 Tetramer [nucleoplasm]
precedingEvent	[Reaction:R-DME-5693540] MRN activates ATM - Drosophila melanogaster [Reaction:R-DME-5682026] MRN bound to shortened telomeres activates ATM - Drosophila melanogaster [Reaction:R-DME-6804762] TP53 forms homotetramers - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5693609
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-2559586] DNA Damage/Telomere Stress Induced Senescence [Pathway:R-DME-6804756] Regulation of TP53 Activity through Phosphorylation [Pathway:R-DME-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks [Pathway:R-DME-69541] Stabilization of p53
(precedingEvent)	[Reaction:R-DME-6799246] CHEK1 phosphorylates TP53 [Reaction:R-DME-69685] CHEK2 phosphorylates TP53
(inferredTo)	[Reaction:R-HSA-5693609] ATM phosphorylates TP53 at S15