Reactome | POLL or POLM extends aligned DNA DSB ends to fill gaps

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POLL or POLM extends aligned DNA DSB ends to fill gaps Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5687358] DNA-directed DNA polymerase activity of p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB ends [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5687359] Orlic-Milacic, Marija, 2015-04-07
dbId	5687360
displayName	POLL or POLM extends aligned DNA DSB ends to fill gaps
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693571] Nonhomologous End-Joining (NHEJ) - Homo sapiens
followingEvent	[Reaction:R-HSA-5693604] XRCC4:LIG4 ligates DNA DSB ends during NHEJ - Homo sapiens
input	[SimpleEntity:R-ALL-30555] dNTP [nucleoplasm] [Complex:R-HSA-5693617] p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB ends [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5687410] Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair [LiteratureReference:5687415] Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts [LiteratureReference:5687412] DNA polymerase lambda can elongate on DNA substrates mimicking non-homologous end joining and interact with XRCC4-ligase IV complex [LiteratureReference:5687406] End-bridging is required for pol mu to efficiently promote repair of noncomplementary ends by nonhomologous end joining [LiteratureReference:5687422] A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	POLL or POLM extends aligned DNA DSB ends to fill gaps
orthologousEvent	[Reaction:R-DDI-5687360] POLL or POLM extends aligned DNA DSB ends to fill gaps - Dictyostelium discoideum [Reaction:R-GGA-5687360] POLL or POLM extends aligned DNA DSB ends to fill gaps - Gallus gallus [Reaction:R-XTR-5687360] POLL or POLM extends aligned DNA DSB ends to fill gaps - Xenopus tropicalis [Reaction:R-DRE-5687360] POLL or POLM extends aligned DNA DSB ends to fill gaps - Danio rerio [Reaction:R-SSC-5687360] POLL or POLM extends aligned DNA DSB ends to fill gaps - Sus scrofa [Reaction:R-BTA-5687360] POLL or POLM extends aligned DNA DSB ends to fill gaps - Bos taurus [Reaction:R-CFA-5687360] POLL or POLM extends aligned DNA DSB ends to fill gaps - Canis familiaris [Reaction:R-RNO-5687360] POLL or POLM extends aligned DNA DSB ends to fill gaps - Rattus norvegicus [Reaction:R-MMU-5687360] POLL or POLM extends aligned DNA DSB ends to fill gaps - Mus musculus
output	[Complex:R-HSA-5687362] p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Extended ligatable DNA DSB ends [nucleoplasm] [SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5693574] XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
revised	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5687360
summation	[Summation:5687411] DNA polymerases mu (POLM) and lambda (POLL) facilitate non-h...

Referrals

(hasEvent)	[Pathway:R-HSA-5693571] Nonhomologous End-Joining (NHEJ)
(precedingEvent)	[Reaction:R-HSA-5693604] XRCC4:LIG4 ligates DNA DSB ends during NHEJ

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