Reactome | PPM1K dephosphorylates p-BCKDH

Schema > Reaction > Entries

PPM1K dephosphorylates p-BCKDH Show undefined attributes

authored	[InstanceEdit:5693146] Jassal, Bijay, 2015-05-14
catalystActivity	[CatalystActivity:5693125] [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity of PPM1K:Mn2+ [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:5693146] Jassal, Bijay, 2015-05-14
crossReference	[DatabaseIdentifier:9917122] RHEA:77248
dbId	5693153
diseaseReaction	[FailedReaction:R-HSA-9912527] H139Hfs13* PPM1K does not dephosphorylate BCKDH - Homo sapiens
displayName	PPM1K dephosphorylates p-BCKDH
edited	[InstanceEdit:5693146] Jassal, Bijay, 2015-05-14
eventOf	[Pathway:R-HSA-70895] Branched-chain amino acid catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-9859148] BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV - Homo sapiens [Reaction:R-HSA-9859172] DLD dimer dehydrogenates dihydrolipoyl - Homo sapiens [Reaction:R-HSA-9859163] DBT transfers BCAA to CoA - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:24670] positive regulation of amino acid metabolic process
input	2 × [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5693140] Structural and biochemical characterization of human mitochondrial branched-chain ?-ketoacid dehydrogenase phosphatase
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PPM1K dephosphorylates p-BCKDH H2O + O-phospho-L-seryl-(3-methyl-2-oxobutanoate dehydrogenase) => L-seryl-(3-methyl-2-oxobutanoate dehydrogenase) + phosphate
negativePrecedingEvent	[NegativePrecedingEvent:9908867] Futile Cycle: BCKDK phosphorylates BCKDH
orthologousEvent	[Reaction:R-GGA-5693153] PPM1K dephosphorylates p-BCKDH - Gallus gallus [Reaction:R-DRE-5693153] PPM1K dephosphorylates p-BCKDH - Danio rerio [Reaction:R-SSC-5693153] PPM1K dephosphorylates p-BCKDH - Sus scrofa [Reaction:R-BTA-5693153] PPM1K dephosphorylates p-BCKDH - Bos taurus [Reaction:R-CFA-5693153] PPM1K dephosphorylates p-BCKDH - Canis familiaris [Reaction:R-RNO-5693153] PPM1K dephosphorylates p-BCKDH - Rattus norvegicus [Reaction:R-MMU-5693153] PPM1K dephosphorylates p-BCKDH - Mus musculus
output	[Complex:R-HSA-70019] BCKDH [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26 [InstanceEdit:9927657] D'Eustachio, Peter, 2024-11-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5693153
summation	[Summation:5693138] The branched-chain alpha-ketoacid dehydrogenase (BCKDH) comp...
updateTrackers	[UpdateTracker:9919514] Update Tracker - [Reaction:5693153] PPM1K dephosphorylates p-BCKDH - v90:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9919514] Update Tracker - [Reaction:5693153] PPM1K dephosphorylates p-BCKDH - v90:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-9912527] H139Hfs13* PPM1K does not dephosphorylate BCKDH
(hasEvent)	[Pathway:R-HSA-70895] Branched-chain amino acid catabolism
(precedingEvent)	[Reaction:R-HSA-9859148] BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV [Reaction:R-HSA-9859172] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-HSA-9859163] DBT transfers BCAA to CoA [NegativePrecedingEvent:9908874] Futile Cycle: PPM1K dephosphorylates p-BCKDH

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