PPM1K dephosphorylates p-BCKDH

Stable Identifier
R-HSA-5693153
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex occupies a strategic point in the branched-chain amino acid (BCAA) catabolic pathway, and careful regulation of its activity is essential for correct BCAA metabolism. The overall activity of the BCKDH complex is controlled by the phosphorylation (inactivation)/dephosphorylation (activation) cycle. Mitochondrial protein phosphatase 1K (PPM1K) dephosphorylates the E1 beta subunit of BCKDH therby regaining its active state. PPM1K requires Mn2+ as a cofactor for phosphatase activity (Wynn et al. 2012).

Literature References
PubMed ID Title Journal Year
22291014 Structural and biochemical characterization of human mitochondrial branched-chain α-ketoacid dehydrogenase phosphatase

Wynn, RM, Li, J, Brautigam, CA, Chuang, JL, Chuang, DT

J. Biol. Chem. 2012
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Catalyst Activity
Title
protein serine/threonine phosphatase activity of PPM1K:Mn2+ [mitochondrial matrix]
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Orthologous Events
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