Reactome | PPM1K dephosphorylates p-BCKDH

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PPM1K dephosphorylates p-BCKDH Show undefined attributes

catalystActivity	[CatalystActivity:10186309] [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity of PPM1K:Mn2+ [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10186311
displayName	PPM1K dephosphorylates p-BCKDH
eventOf	[Pathway:R-RNO-70895] Branched-chain amino acid catabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9859172] DLD dimer dehydrogenates dihydrolipoyl - Rattus norvegicus [Reaction:R-RNO-9859163] DBT transfers BCAA to CoA - Rattus norvegicus [Reaction:R-RNO-9859148] BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV - Rattus norvegicus
goBiologicalProcess	[GO_BiologicalProcess:24670] positive regulation of amino acid metabolic process
inferredFrom	[Reaction:R-HSA-5693153] PPM1K dephosphorylates p-BCKDH - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [Complex:R-RNO-5693120] p-BCKDH [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	PPM1K dephosphorylates p-BCKDH H2O + O-phospho-L-seryl-(3-methyl-2-oxobutanoate dehydrogenase) => L-seryl-(3-methyl-2-oxobutanoate dehydrogenase) + phosphate
output	[Complex:R-RNO-70019] BCKDH [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5693153
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-70895] Branched-chain amino acid catabolism
(precedingEvent)	[Reaction:R-RNO-9859172] DLD dimer dehydrogenates dihydrolipoyl [Reaction:R-RNO-9859163] DBT transfers BCAA to CoA [Reaction:R-RNO-9859148] BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV
(inferredTo)	[Reaction:R-HSA-5693153] PPM1K dephosphorylates p-BCKDH

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