Cellular iron homeostasis is maintained by the coordinate posttranscriptional regulation of iron metabolism genes. The E3 ubiquitin ligase complex comprising the F-box/LRR-repeat protein 5 (FBXL5) protein, S-phase kinase-associated protein 1 (SKP1), cullin 1 (CUL1) and NEDD8. NEDD8 (Neddylin, Neural precursor cell expressed developmentally down-regulated protein 8) is a ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. NEDD8 covalently attachs to cullins (eg CUL1) and activates their associated E3-ubiquitin ligase activity thus promoting polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (Hori et al. 1999).
Kato, S, Shimbara, N, Miyamoto, C, Osaka, F, Okabayashi, K, Chiba, T, Tanaka, K, Hori, T
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